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JoVE Journal Bioengineering
Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
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Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Article DOI: 10.3791/59549-v • 09:09 min • May 2nd, 2019
May 2nd, 2019 •
1, 1, 1,2,3
1Department of Chemical Engineering, University of Mississippi, 2Department of BioMolecular Sciences, University of Mississippi, 3Biomedical Engineering Program, University of Mississippi

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Methods to prepare and characterize the physicochemical properties and bioactivity of neutrally-charged, pH-responsive siRNA nanoparticles are presented. Criteria for successful siRNA nanomedicines such as size, morphology, surface charge, siRNA loading, and gene silencing are discussed.

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Neutrally-charged PH-responsive Polymeric Nanoparticles SiRNA Delivery Nanoparticles Characterization Bioavailability Of SiRNA Systemic Administration Treat Diseases Cancer Cardiovascular Disease Autoimmune Disorders Dissolve Polymer Ethanol Concentration Stir Pipette Citric Acid Buffer Water Small Interfering RNA Nitrogen To Phosphate Ratio Ambient Temperature Phosphate Buffer
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