Waiting
Elaborazione accesso...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Neuroscience / Intrathecal Delivery of Antisense…
JoVE Journal
Neuroscience

È necessario avere un abbonamento a JoVE per visualizzare questo Contenuto.

JoVE Journal Neuroscience
Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System
In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films
Journal (Neuroscience)
In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films
Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination
Journal (Neuroscience)
Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination
 

Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System

Article DOI: 10.3791/60274-v • 07:47 min • October 29th, 2019
October 29th, 2019 •
*1, *2, *1, 1, 1, 1, 1
1Biogen, Inc., 2Ionis Pharmaceuticals
* These authors contributed equally

Capitoli

Riepilogo
Automatic Translation

Here, we describe a method for delivering drugs to the rat central nervous system by implanting a catheter into the lumbar intrathecal space of the spine. We focus on the delivery of antisense oligonucleotides, though this method is suitable for delivery of other therapeutic modalities as well.

Tags

Intrathecal Delivery Antisense Oligonucleotides Rat Central Nervous System Pharmacokinetics Pharmacodynamics Efficacy Therapeutics Disease Models Guide Cannulas Catheter Wire Assembly Intrathecal Catheter Delivery Catheter Assembly PE10 Tubing PE50 Catheter
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter