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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Article DOI: 10.3791/60314-v • 05:36 min • February 8th, 2020
February 8th, 2020 •
*1, *1, 2, 3, 4, 5, 6, 7, 1, 1,8
1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, 2Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, 3Department of Bioengineering, Hanyang University, 4Department of Ecology and Evolutionary Biology, University of California, Los Angeles, 5Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, 6School of Life Sciences, Beijing Normal University, 7Department of Urology, West China Hospital, Sichuan University, 8Department of Urology, David Geffen School of Medicine, University of California, Los Angeles
* These authors contributed equally

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Metastatic clear cell renal cell carcinoma is a disease without a comprehensive animal model for thorough preclinical investigation. This protocol illustrates two novel animal models for the disease: the orthotopically implanted mouse model and the chicken chorioallantoic membrane model, both of which demonstrate lung metastasis resembling clinical cases.

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Metastatic Clear Cell Renal Cell Carcinoma CCRCC Mouse Kidney Model Chicken Chorioallantoic Membrane Model Metastasis Lung Metastasis Animal Models Tumor Growth Circulating Tumor Cells Molecular Mechanism Therapy Outcome Surgery Implantation Renal Capsule Embryo Hatching
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