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Journal / Developmental Biology / Displacement Analysis of Myocardial Mechanical…
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Developmental Biology

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Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish
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Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish

Article DOI: 10.3791/60547-v • 09:15 min • February 6th, 2020
February 6th, 2020 •
1, 1,2,3
1Division of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, 2Ronald Reagan UCLA Medical Center, 3Veterans Affairs West Los Angeles Medical Center

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The goal of this protocol is to detail a novel method for the assessment of segmental cardiac function in embryonic zebrafish under both physiological and pathological conditions.

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DIAMOND Displacement Analysis Myocardial Mechanical Deformation Cardiac Function Embryonic Zebrafish Open Source Method Quantitative Assessment Micrometer Resolution Local Cardiac Mechanics Injury Patterns Doxorubicin-induced Cardiac Toxicity High Throughput Screening Chemotherapy-induced Cardiac Toxicity Mammalian Heart Muscle Fiber Orientation Rotational Motion Twisting Motion Anatomical Structure Zebrafish Heart Ventricle Segmentation 3D Reconstruction Systolic Phase Diastolic Phase
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