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Journal / Neuroscience / Induction of Diffuse Axonal Brain Injury in Rats…
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Induction of Diffuse Axonal Brain Injury in Rats Based on Rotational Acceleration

Article DOI: 10.3791/61198-v • 06:14 min • May 9th, 2020
May 9th, 2020 •
*1, *2, 3, 1, 1, 4, 4, 5, 1, 1
1Division of Anesthesia and Critical Care, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 2Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 3Department of Anesthesiology, Yale University School of Medicine, 4Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, 5Department of microbiology and immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev
* These authors contributed equally

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Automatic Translation

This protocol validates a reliable, easy-to-perform and reproducible rodent model of brain diffuse axonal injury (DAI) that induces widespread white matter damage without skull fractures or contusions.

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Diffuse Axonal Brain Injury Rotational Acceleration Traumatic Brain Injury Rat Model Sprague-Dawley Rats Experimental Setup Rotational Mechanism Head Fixation Pins Lateral Head Rotation Device Recovery Room Force Applied Moment Of Force Kinetic Energy Falling Weight Gravitational Acceleration Height Distance Between Ear Pins Neurological Deficit Neurological Severity Score Mobility Assessment
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