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A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Article DOI: 10.3791/62139-v • 07:31 min • May 3rd, 2021
May 3rd, 2021 •
1,2,3,4, 5, 1, 6, 7, 8, 9, 10, 4, 1,2
1Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, 2Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 3Department of Surgery, Johns Hopkins University School of Medicine, 4Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 5Program for Comparative Medicine, Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, 6Tuskegee College of Veterinary Medicine, 7Department of Human Pathology, Juntendo University Faculty of Medicine, 8Department of Surgery, Juntendo University Shizuoka Hospital, Juntendo University School of Medicine, 9Department of Urology, The Johns Hopkins School of Medicine, 10Department of Gastroenterology and Minimally Invasive Surgery, Juntendo University Faculty of Medicine

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Here, a syngeneic orthotopic implantation followed by an amputation procedure of the osteosarcoma with spontaneous pulmonary metastasis that can be used for preclinical investigation of metastasis biology and development of novel therapeutics is described.

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Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model Amputation Metastasis Rate Pulmonary Metastasis Cancer Therapies Immune System Jugular Injections Intravenous Drug Delivery Nanoparticles Radiolabeled Ligands Limb Amputation Blood Loss Penile Reflex Anesthetized Rat Surgical Area Disinfection 22-gauge Needle
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