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A Modified Simple Method for Induction of Myocardial Infarction in Mice

Article DOI: 10.3791/63042-v • 04:29 min • December 3rd, 2021
December 3rd, 2021 •
*1,2, *1,2, *2, 1, 1, 1,2
1Department of Cardiology, The First Affiliated Hospital of Bengbu Medical College, 2Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
* These authors contributed equally

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Under adequate anesthesia, the mouse heart was externalized through the intercostal space, and myocardial infarction was successfully induced by ligating the left anterior descending artery (LAD) using materials readily available in most laboratories.

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Modified Simple Method Induction Of Myocardial Infarction MI Models Post-MI Remodeling Novel Therapeutics Isoproterenol Treatment Cryoinjury Coronary Artery Ligation Ischemic Response Chronic Remodeling Technical Challenges Readily Available Materials Mouse Chest Skin Intercostal Space Pectoralis Major Pectoralis Minor Left Anterior Descending Branch (LAD) 6-0 Suture 2,3,5-Triphenyltetrazolium Chloride (TTC) Scar Size Changes Survival Analysis Results Cardiac Rupture Echocardiographic Assessment
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