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Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model

Article DOI: 10.3791/63172-v • 05:52 min • November 4th, 2021
November 4th, 2021 •
*1,2, *3, 3, 3, 1,3, 3,4, 3,4, 1,3,4
1ICREC Research Program, Germans Trias i Pujol Health Research Institute (IGTP), 2Faculty of Medicine, University of Barcelona (UB), 3Heart Institute (iCOR), Germans Trias i Pujol University Hospital, 4CIBER Cardiovascular, Instituto de Salud Carlos III
* These authors contributed equally

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Myocardial infarction (MI) animal models that emulate the natural process of the disease in humans are crucial to understanding pathophysiological mechanisms and testing the safety and efficacy of new emergent therapies. Here, we describe an MI swine model created by deploying a percutaneous embolization coil.

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Myocardial Infarction Percutaneous Embolization Coil Deployment Swine Model Translational Animal Model Feasible Reproducible Open-chest Surgery Postoperative Inflammation Mimicking Human Myocardial Infarction Modeling Myocardial Infarction Ischemic Area Anesthetized Animal Operating Table Supine Position Electrocardiogram Probes ST-segment T-waves Heart Rate Pulse Oximeter Non-invasive Pressure Cuff Femoral Area Surgical Soap Antiseptic Povidone-iodine Solution Alcohol Sterile Conditions Sterile Gown Sterile Gloves Needle Vascular Sheath J-tipped Wire Guiding Catheter Guidewire Microcatheter Contrast Medium Injection Manifold Kit
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