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JoVE Journal Bioengineering
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A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Article DOI: 10.3791/63312-v • 12:55 min • December 9th, 2021
December 9th, 2021 •
1, 2, 3, 4, 5, 1,2,6
1Department of Mechanical Engineering, Temple University, 2Department of Bioengineering, Temple University, 3Department of Bioengineering, University of Toledo, 4Biomedical Technology, CFD Research Corporation, 5Center for Inflammation and Lung Research, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine, Temple University, 6Department of Radiation Oncology, Lewis Katz School of Medicine, Temple University

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Automatic Translation

In this protocol, a biomimetic microfluid assay, which can reproduce a physiologically relevant microvascular environment and reproduce the entire leukocyte adhesion/migration cascade, is employed to study leukocyte-endothelial cell interactions in inflammatory disease.

Tags

Microphysiological System Leukocyte-endothelial Cell Interaction Inflammation Sepsis Vascular Endothelium Barrier Function Leukocyte Trafficking Organ Damage Biomimetic Microfluidic Assay (bMFA) Rolling Firm Adhesion Spreading Migration Of Neutrophils Primary Human Cells Patient Samples Clinical Translation Therapeutics Qingliang Yang Graduate Research Assistant Ports Fine Forceps Jaw Clamps Fibronectin Stock Solution PBS Syringe Blunt Needle
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