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Microfluidic Device for the Separation of Non-Metastatic (MCF-7) and Non-Tumor (MCF-10A) Breast Cancer Cells Using AC Dielectrophoresis

Article DOI: 10.3791/63850-v • 08:33 min • August 11th, 2022
August 11th, 2022 •
1, 2, 3, 4,5
1Department of Biomedical Engineering, Foundation University Islamabad, 2College of Medical Technology, The Islamic University Najaf, 3Faculty of Mechanical Engineering, University of Tabriz, 4Department of Engineering Mathematics, University of Bristol, 5School of Life Sciences, University of Warwick

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Breast cancer cells exhibit different dielectric properties compared to non-tumor breast epithelial cells. It has been hypothesized that, based on this difference in dielectric properties, the two populations can be separated for immunotherapy purposes. To support this, we model a microfluidic device to sort MCF-7 and MCF-10A cells.

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Microfluidic Device Separation Non-metastatic Breast Cancer Cells Non-tumor Breast Cells AC Dielectrophoresis Conductivity Applied Frequency Simulation-based Example Inline Separation Dielectric Properties Multiphysics Software Blank Model Global Definitions Parameters Table One 2D Component Geometry Model File Blank Material Material Properties AC/DC Physics Electric Currents Channel Walls Electrodes Current Conservation Insulate Electric Potential
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