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Journal / Neuroscience / 老化研究のためのiPS細胞由来脳オルガノイドの長期培養のための堅牢な組織作製…
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Neuroscience

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JoVE Journal Neuroscience
老化研究のためのiPS細胞由来脳オルガノイドの長期培養のための堅牢な組織作製
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老化研究のためのiPS細胞由来脳オルガノイドの長期培養のための堅牢な組織作製

Article DOI: 10.3791/64586-v • 08:20 min • May 12th, 2023
May 12th, 2023 •
1, 2,3, 1
1Department of Applied Stem Cell Technologies, TechMed Centre Enschede, University of Twente, 2Centro de Biotecnología-FEMSA, Tecnologico de Monterrey, 3Department of Genetics, Harvard Medical School

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本プロトコルは、ヒト誘導多能性幹細胞(iPSC)由来の脳オルガノイドの再現性のある生成、維持、および老化のための段階的な手順を提供します。この方法により、脳オルガノイドを長期間培養・成熟させることができ、脳の老化や加齢に伴う病態形成に関わる過程のモデル化が容易になります。

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神経科学、第195号、
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