Name: nuclear dna and cell control
Uploaded: 2019-03-11T09:21:03.000Z
Duration: 1 min 32 s
Channel: JoVE

K12 Standards

north-carolina-k-12-science-standard-course-of-study

North Carolina K-12 Science Standard Course of Study

9-12

Biology

from-molecules-to-organisms-structures-and-processes

From Molecules to Organisms- Structures and Processes

LS.Bio.1.3

The Nucleus

真核細胞の 大きな特徴である核は、遺伝情報(DNA)を収容する 膜結合型オルガネラです。細胞のライフサイクルの段階に応じた 方法で編成されています。例えば、クロマチンとして知られる DNAタンパク質複合体は，ゲル様物質の核質に懸濁されます。特に核小体と呼ばれる領域に 集中しています。細胞が分裂していないとき、クロマチン繊維は ゆるく配置されていて、もつれた糸のようになっています。転写中にDNAへのアクセスを容易にします。対照的に、細胞がクロマチン線維を分裂させようとしているとき、クロマチン繊維は染色体に圧縮されます。核小体はまた、リボソームのサブユニット、すなわち転写に必要な構造が作られる場所でもあります。核を取り囲むのは、内側の核プラズマと細胞質との間のイオン、分子、リボソーム部分およびメッセンジャーRNAの 流れを制御するためのタンパク質内張り孔を含んでいる 二重膜核エンベロープです。体内のほとんどの細胞は1つの核を持っていますが、赤血球のような細胞は 無核とよばれ，核が存在しません。また，例えば骨格筋細胞のような細胞は，構造的および 機能的な必要性のために 複数の核で多核化されています。

「導入された核」 Cold Spring Harbor Perspectives in Biology 3, no. 5 (May 2011).[<a href="https://doi.org/10.1101/cshperspect.a000521" target="__blank">ソース</a>]
「細胞核の機能的組織とダイナミクス」 Frontiers in Plant Science 5 (2014年8月12日).[<a href="https://doi.org/10.3389/fpls.2014.00378" target="__blank">ソース</a>]

核は、真核生物の遺伝情報を染色体DNAの形で保持している膜結合型の細胞小器官です。これは、ミトコンドリアや葉緑体のDNAとは異なり、それらの器官に特有の機能を担っています。赤血球のように核を持たない細胞や、骨格筋細胞のように複数の核を持つ細胞もありますが、多くの真核性細胞は1つの核を持ちます。 
 
 核内のDNAはヒストンなどのタンパク質に巻きついており、クロマチンと呼ばれるDNAとタンパク質の複合体を形成します。細胞が分裂せず、細胞周期の間期にある時、クロマチンは散在しています。これは、DNAコードに基づいてメッセンジャーRNA（mRNA）が合成される転写の過程において、DNAへの接近を容易にします。真核細胞がまさに分裂しようとするとき、クロマチンはしっかりと凝縮し、明確に糸状の染色体になります。人間は全部で46本の染色体を持ちます。
 
 クロマチンは、核の中でも特に「核小体」と呼ばれる領域に集まっています。核小体は、mRNAをタンパク質に翻訳するリボソームの生成に重要な役割を果たしています。核小体では、リボソームRNAが合成され、タンパク質と結合してリボソームサブユニットとなり、後に細胞質で機能するリボソームを形成します。 
 
 核の内部は、核質と呼ばれるゲル状の物質で満たされます。核の周囲には核膜と呼ばれる2枚の脂質二重層からなる二重膜があります。核膜には、タンパク質でできた小さな開口部（孔）が点在しており、核内へ出入りする物質を管理します。例えば、核外に出たmRNAは、孔を通ってリボソームに送られ、直接タンパク質に翻訳されます。

核は、真核細胞の制御センターとして機能する膜結合オルガネラです。それは遺伝子発現を制御する染色体DNAを含んでいます...

Education

JoVE Core

生物学

Cellular Processes

細胞プロセス

Cell Structure and Function

細胞の構造と機能

KEY TERMS AND CONCEPTS

主要用語と概念

nuclear dna and cell control

The nucleus is the control center of a eukaryotic cell. It is a membrane-bound organelle that contains chromosomal DNA. That DNA helps control gene expression and regulate protein production in the cell.

Not all cellular DNA has the same role. The DNA in mitochondria and chloroplasts supports functions that are specific to those organelles. Inside the nucleus, DNA structure also affects how genes are regulated.

Nuclear DNA is wrapped around proteins called histones. This forms chromatin, a DNA-protein complex. During interphase, when the cell is not dividing, chromatin stays loosely arranged. This open form makes the DNA easier to access during transcription.

When a eukaryotic cell prepares to divide, chromatin changes shape. It condenses into distinct, linear chromosomes. These chromosomes can then be separated into daughter cells.

The nucleus also contains the nucleolus. This is a membrane-less organelle that forms around the chromosomal loci for ribosomal RNA, or rRNA. The nucleolus is the site where rRNA is made and ribosomal subunits are assembled. These subunits leave the nucleus and later combine to form functional ribosomes.

Other nuclear bodies are found in the nucleus as well. These include Cajal bodies, speckles, and paraspeckles. They help organize the nuclear space and create separate sites for specific biological reactions. Their membrane-less structure also allows contents to move more easily with the nucleoplasm.

Nuclear DNA and Cell Control

what are cells?

Cell Membrane, DNA, and Organelles

Cells are the basic units of life, from a bacterium made of one cell to a human made of trillions. Even though organisms can differ greatly, their cells share key features that support life. A cell has a plasma membrane, which is a lipid bilayer that separates the cytoplasm from the outside environment. It also contains DNA, the genetic material that carries instructions for the cell. In prokaryotic cells, DNA is found in a region called the nucleoid. In eukaryotic cells, DNA is enclosed...

cell size

Why Cell Size Is Limited

Cell size is limited by surface area and diffusion. Cells vary widely in size, both between organisms and within the same organism. Bacterial cells are usually 1 to 10 micrometers wide, and the smallest bacteria can be 0.1 micrometers in diameter. That is about a thousand times smaller than most eukaryotic cells, which are typically 10 to 100 micrometers across. A cell takes in nutrients and water through diffusion across the plasma membrane or through channels in the membrane. The membrane...

eukaryotic compartmentalization

Cell Organelles and Microenvironments

Eukaryotic cells use membrane-bound organelles to keep cell processes organized. The nucleus and mitochondria are two key examples. Because biological membranes are selectively permeable, they create controlled spaces inside each organelle. These small microenvironments support specialized jobs and separate them from the surrounding cytosol. Different organelles maintain different internal conditions. In animal cells, lysosomes keep an acidic environment that helps their enzymes digest...

prokaryotic cells

Prokaryotic Cell Structures

Prokaryotic cells are small, single-celled organisms found in the domains Archaea and Bacteria. Bacteria include familiar species such as Salmonella and E. coli. Archaea include extremophiles, which are organisms that live in harsh environments like volcanic springs. Prokaryotic cells share several basic features with eukaryotic cells. They are surrounded by a plasma membrane, contain cytoplasm, and have ribosomes that make proteins. Their genetic material is a single, circular DNA molecule.

cytoplasm

Cytoplasm and the Cell’s Internal Framework

The cytoplasm is the cell’s internal space that holds organelles and the cytoskeleton. It is suspended in the cytosol, an aqueous fluid made of water, ions, salts, and many organic molecules. Together, these parts create the environment where key cell activities happen. The cytoplasm is also a major site for protein synthesis and folding. The water-based cytosol helps proteins fold correctly. Hydrophobic amino acid side chains tend to hide in the protein core, while hydrophilic amino acids...

endoplasmic reticulum

ER in Protein and Lipid Transport

The endoplasmic reticulum is a membrane network in eukaryotic cells. It is continuous with the outer membrane of the nucleus. This connection helps link nuclear and cytoplasmic processes and supports efficient movement inside the cell. mRNA can move from the nucleus to ribosomes, which helps protein synthesis happen efficiently. The ER is a major site for making, processing, and distributing biomolecules. The rough endoplasmic reticulum has ribosomes attached to its surface. These ribosomes...

ribosomes

How Ribosomes Build Proteins

Ribosomes build proteins by reading messenger RNA, or mRNA, and linking amino acids in the right order. Both prokaryotic and eukaryotic cells contain ribosomes. Cells that make large amounts of protein, such as secretory cells in the human pancreas, can have millions of them. Ribosomes are made of ribosomal RNA, or rRNA, and proteins. In eukaryotic cells, rRNA is transcribed from genes in the nucleolus, a part of the nucleus that specializes in making ribosomes. There, rRNA combines with...

golgi apparatus

Protein Sorting in the Golgi Apparatus

The Golgi apparatus sorts and modifies proteins after they leave the endoplasmic reticulum (ER). Properly folded and assembled proteins are packaged into vesicles, or small membrane sacs, and moved by microtubule-based motor proteins. These vesicles can fuse into vesicular tubular clusters before reaching the Golgi, which often looks like a ribbon-shaped organelle in eukaryotic cells. Vesicles enter the cis face of the Golgi, the side facing the ER. They pass through a set of pancake-shaped...

peroxisomes

Peroxisomes and Cellular Detoxification

Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration, which turns energy from food into ATP. Peroxisomes focus on breaking down substances such as fatty acids and other materials the cell needs to process. A peroxisome is a single membrane-bound organelle. It helps with lipid metabolism and chemical detoxification. Enzymes inside peroxisomes move hydrogen atoms from molecules to oxygen. This reaction...

microtubules

Microtubules in Cells and Cell Movement

Microtubules are cytoskeletal fibers that help cells keep their shape, move materials, and divide. They are the thickest of the three main cytoskeletal structures in eukaryotic cells, with a diameter of about 25 nm. Along with microfilaments and intermediate filaments, they form the internal support network of the cell. Microtubules are hollow tubes built from tubulin proteins. Each tubulin molecule is a heterodimer, which means it has two different parts: α-tubulin and β-tubulin. These dimers...

plant cell wall

Plant Cell Walls in Growth and Support

Plant cell walls help plant cells keep their shape, stay protected, and remain supported. As a cell matures, its wall can change based on the cell type. Parenchyma cells in leaves usually have only a thin primary cell wall. These walls are part of how different plant cells take on different jobs. Collenchyma and sclerenchyma cells are found mostly in the outer layers of stems and leaves. Collenchyma cells add strength by partially thickening the primary cell wall. Sclerenchyma cells provide...

plasmodesmata

Plasmodesmata and Plant Cell Communication

Plasmodesmata are the connections that let plant cells communicate directly. These tiny passageways link neighboring cells through the cell wall and help tissues work together in a multicellular plant. Cells in multicellular organisms must communicate to function as a unit. One way they do this is through intercellular junctions, which are contact points between adjacent cells. Fungal, plant, and animal cells all have intercellular junctions, but the types differ. In animal cells, the main...

the nucleus

The nucleus is the control center of a eukaryotic cell. It is a membrane-bound organelle that contains chromosomal DNA. That DNA helps control gene expression and regulate protein production in the cell. Not all cellular DNA has the same role. The DNA in mitochondria and chloroplasts supports functions that are specific to those organelles. Inside the nucleus, DNA structure also affects how genes are regulated. Nuclear DNA is wrapped around proteins called histones. This forms chromatin, a...

the extracellular matrix

How ECM Supports Animal Tissues

The extracellular matrix (ECM) supports animal tissues by surrounding cells with structural molecules. It helps maintain tissue organization and gives tissues their specific physical properties. The ECM includes a gel-like ground substance, fibrous components, and many molecules with different jobs. A major part of the ECM is made of glycosaminoglycans, or GAGs. These polysaccharides fill much of the extracellular space and can take up a large volume for their mass. That makes the matrix...

gap junctions

Connexins and Cell-to-Cell Signaling

Gap junctions help animal cells send signals and share small materials with nearby cells. They are made of special proteins that form pores between neighboring cells and connect their cytoplasm. Through these channels, cells can exchange ions and other small molecules. These communication channels are found in many invertebrate and vertebrate species. They support important processes such as cell differentiation and development. They are also linked to human diseases, including disorders of...

tissues

Body Tissues and Their Jobs

Body tissues are groups of cells with similar structure and function. When different tissues work together, they form an organ with a specialized job. Vertebrates have four main tissue types: epithelial, connective, muscle, and nervous tissue. Epithelial tissue is made of thin sheets of cells. It covers the skin and lines internal organs and body cavities. These cells are tightly packed, so they help protect against injury, infection, and water loss. Epithelial tissue may be simple, with one...

key terms and concepts

Explore how the nucleus stores DNA, controls gene expression, packages chromatin, forms chromosomes, and builds ribosomal subunits in high school cells.

Nuclear DNA and Cell Control | JoVE K12

JoVE Core series brings biology to life through over 300 concise and easy-to-understand animated video lessons that explain key concepts in biology, plus more than 150 scientist-in-action videos that show actual research experiments conducted in today’s laboratories.

biology

JoVE Core シリーズは、生物学の重要な概念を説明する 300 を超える簡潔でわかりやすいアニメーション ビデオ レッスンに加え、今日の研究室で行われる実際の研究実験を示す 150 以上の科学者の活動ビデオを通じて、生物学に命を吹き込みます。

Pennsylvania State Academic Standards

Life Science

Structure and Function

3.1.9-12.A

ohios-learning-standards-and-model-curriculum

Ohio’s Learning Standards and Model Curriculum

Cells

Cell structure and function

Virginia  Standards of Learning

HIgh School

BIO.3

BIO.3.a

Arizona Science Standards

High School

HS+B.L1

HS+B.L1U1.4

Alabama Course of Study Science

From Molecules to Organisms: Structures and Processes

9-12.B.1.1

Florida Department of Education

SC.912.L.14

SC.912.L.14.2

SC.912.L.14.3

new-york-state-science-learning-standards

New York State Science Learning Standards

HS-LS1-1.

Next Generation Science Standards

HS-LS1-1

myJoVE Corporation

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Introduction to Enzymes

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Ribozymes

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LS.Bio.1.2

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Prokaryotic Cells

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Cytoplasm

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The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression ...

Endoplasmic Reticulum

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Ribosomes

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Golgi Apparatus

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Lysosomes

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Peroxisomes

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Background
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Types of Intermediate Filaments

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Analyze how the relationship between structure and function supports life processes within organisms.

Nuclear DNA and Cell Control

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