細胞接着分子 - 種類と機能

The four major families of cell adhesion molecules are integrins, cadherins, selectins, and immunoglobulin-like proteins. Integrins primarily mediate cell interactions with the extracellular matrix. Cadherins form stable cell-cell interactions, while selectins and immunoglobulin-like cell adhesion molecules create transient interactions that help recruit and direct free-moving cells like immune cells to target sites.

Cadherins form stable, long-lasting cell interactions by binding cadherins on adjacent cells, making them essential for tissue organization in epithelial tissues. Selectins, by contrast, bind specific carbohydrates on other cell surfaces and form transient interactions. This difference allows cadherins to maintain tissue structure while selectins facilitate temporary cell recruitment and movement.

Cell adhesion molecules hold cells together and enable transmembrane communication essential for coordinated tissue functioning. They provide mechanical strength to tissues and act as receptors for signal transmission across the plasma membrane. In stable tissues like the endothelium, strong CAM interactions support tissue organization, while weaker interactions help recruit immune cells to specific locations.

Integrins primarily mediate a cell's interaction with its surrounding extracellular matrix rather than directly with other cells. However, some integrins can bind to immunoglobulin-like cell adhesion molecules on other cell surfaces, enabling direct cell-cell interactions. For example, integrins on immune cells bind to IgCAMs on vascular endothelium to facilitate immune cell recruitment.

The complexity of cellular interactions increases with organism complexity, requiring more diverse CAM types. While the fruit fly D. melanogaster has approximately 500 genes coding for cell adhesion molecules, complex vertebrates like mammals have over a thousand CAM genes. This expanded genetic repertoire enables the sophisticated tissue organization and cell communication required in multicellular organisms.

Selectins and immunoglobulin-like proteins form transient interactions that allow cells to recognize and move toward target sites. These molecules participate in selective recruitment of lymphocytes to secondary lymphoid organs by binding specific carbohydrates or proteins on target cell surfaces. Their temporary binding nature enables cells to detach and continue migration once they reach their destination.

Cell adhesion molecules are fundamental to multicellularity, found across virtually all multicellular organisms from sponges to complex vertebrates. CAMs enable physical interactions between cells and provide the mechanical strength necessary for tissue formation and organization. The diversity and complexity of CAM families increase with organism complexity, supporting the coordinated functioning of tissues and organ systems.