2 コンパートメントオープンモデル: IV ボーラス投与

The two-compartment model for intravenous bolus administration comprises central and peripheral compartments, representing the distribution of a drug in the body.

First-order distribution rate or transfer constants like k₁₂ and k₂₁ denote the reversible drug transfer rate between compartments.

The hybrid first-order constants for the rapid distribution and slow elimination depend on k₁₂, k₂₁, and the elimination rate constant from the central compartment k₁₀ .

The plasma concentration-time profile post-IV bolus administration follows a biexponential curve, indicating distribution and elimination phases.

The method of residuals can resolve the biexponential distribution curve into individual exponents. The slope of the residual line obtained from the semilog plot of plasma drug concentration values versus time yields the transfer constants.

The elimination half-life is calculable from the elimination rate constant for the entire body β.

Other pharmacokinetic parameters, such as volume of distribution and clearance, can be determined.