Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

J. Hunter Scarborough; Paulina Gonzalez; Sean Rodich; Kayla N. Green

doi:10.3791/52399

ジャーナル

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化学

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固相樹脂系の方法論を経由して、非対称フェロセン派生バイオコンジュゲートシステムのための合成方法論

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

JoVE Journal
化学

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JoVE Journal 化学

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

固相樹脂系の方法論を経由して、非対称フェロセン派生バイオコンジュゲートシステムのための合成方法論

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9,629 Views

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07:07 min

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March 12, 2015

DOI:

10.3791/52399-v

DOI:

10.3791/52399-v

•

07:07 min

March 12, 2015

•

2 Views

J. Hunter Scarborough¹, Paulina Gonzalez¹, Sean Rodich¹, Kayla N. Green¹

¹化学科,Texas Christian University

概要

The synthesis of asymmetric species of ferrocene is challenging using solution techniques. This report focuses on the methods carried out to produce a ferrocene-biotin bioconjugate using facile and clean reactions accomplished via solid-phase synthesis. Incorporation of a thiolate moiety is shown to impart the ability for immobilization on gold surfaces.