Why does voltage mapping under 0.5 mV matter for target validation?

Scientific Value: Enables interrogation of ventricular tachycardia mechanisms by defining scar-related slow conduction zones and abnormal electrograms.
Operational Value: Provides reproducible voltage-based segmentation of scar, border zone, and healthy tissue for consistent target identification.
Predictive Value: Supports functional validation of arrhythmogenic substrates through detection of fractionated and late potentials linked to reentry maintenance.

Defining scar areas with voltage below 0.5 millivolts identifies regions of slow conduction critical for reentrant ventricular tachycardia maintenance, enabling precise substrate targeting in ablation planning.

How does isolating ventricular complexes by morphology improve mapping accuracy?

Using morphology matching to exclude unwanted ventricular complexes ensures only physiologically relevant signals are included in the electro-anatomical map, reducing noise and improving substrate definition fidelity.

What enables detection of fractionated and late potentials in scar areas?

The close electrode spacing of the multipolar catheter allows detection of multi-component ventricular action potentials and clearly separated second activations, which are tagged as fractionated or late potentials indicating slow conduction zones.

Why is verifying inducible ventricular tachycardia post-ablation important for cross-functional collaboration?

Re-performing programmed ventricular stimulation after ablation assesses whether substrate modification was successful, providing a functional endpoint that informs go/no-go decisions across discovery, preclinical, and clinical teams.

What statistical or analytical capability is required before implementing this mapping approach?

The ability to quantify and stratify electro-anatomical data by voltage (1.5 mV normal) and electrogram morphology is essential to enable reproducible substrate modification and outcome comparison.