誘導多能性幹細胞由来肝細胞を用いた家族性高コレステロール血症ひと肝臓キメラマウスモデル

7.6K 回視聴

5 件の引用

10:56 分

2018年9月15日

10.3791/57556-v

2018年9月15日

7.6K 回視聴

Jiayin Yang^*¹^,²^,⁶ , Lai-Yung Wong^*² , Xiao-Yu Tian^*³ , Rui Wei¹^,² , Wing-Hon Lai² , Ka-Wing Au² , Zhiwei Luo⁴^,⁵ , Carl Ward⁴^,⁵ , Wai-In Ho² , David P. Ibañez⁴^,⁵ , Hao Liu⁴^,⁵ , Xichen Bao⁴^,⁵ , Baoming Qin⁴^,⁵ , Yu Huang³ , Miguel A. Esteban⁴^,⁵^,⁷ , Hung-Fat Tse¹^,²^,⁶^,⁷

¹Department of Medicine, University of Hong Kong-Shenzhen Hospital, ²The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, ³School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, ⁴Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, ⁵Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, ⁶Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine, University of Hong Kong, ⁷Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre, University of Hong Kong and Guangzhou Institutes of Biomedicine and Health

^* These authors contributed equally

ここでは、ひと誘導多能性幹細胞由来肝細胞を用いた家族性高コレステロール血症のひと肝臓キメラマウスモデルを生成するためのプロトコルを提案する.高コレステロール血症の新しい治療法をテストするための貴重なモデルです。

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Chapters in this video

0:04

Title

0:53

Dissociation of iHeps for Injection

4:22

Intrasplenic Injection of iHeps

6:11

Endothelial Function Test

9:18

Results: iHep Mediated Repopulation of LRG Mice Liver

10:39

Conclusion

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