回転加速度に基づくラットにおけるびまん軸索脳損傷の誘導
8.2K 回視聴
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8 件の引用
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06:14 分
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2020年5月9日
DOI :10.3791/61198-v
2020年5月9日
•8.2K 回視聴
Dmitry Frank*1 , Israel Melamed*2 , Benjamin F. Gruenbaum3 , Julia Grinshpun1 , Ruslan Kuts1 , Rachel Shvartsur4 , Abed N. Azab4 , Mohamad H. Assadi5 , Max Vinokur1 , Matthew Boyko1
1Division of Anesthesia and Critical Care, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 2Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 3Department of Anesthesiology, Yale University School of Medicine, 4Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, 5Department of microbiology and immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev
* These authors contributed equally
このプロトコルは、頭蓋骨骨折や挫傷なしに広範囲にわたる白質損傷を誘発する脳びまん軸索損傷(DAI)の信頼性の高い、実行しやすく、再現可能なげっ歯類モデルを検証する。
Chapters in this video
0:04
Introduction
0:45
Preparing Rats for the Experimental Procedure
1:11
Procedure of Induction Diffuse Axonal Brain Injury
1:54
Measurement of Rotational Kinematics, Biomechanical Parameters
2:32
Evaluation of Neurological Severity Score after 48 hours
3:08
Brain Collection for Histological Examination after 48 hours
4:02
Immunohistochemical Staining
4:16
Results
5:22
Conclusion
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