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All procedures involving animal models have been reviewed by the local institutional animal care committee and the JoVE veterinary review board.
1. Accelerating Rotarod
- Acclimate subjects to the assay room 10 min prior to the start of the trial. During this acclimation period, prepare the rotarod apparatus, cleaning each lane of the apparatus with 30% ethanol.
- Open the rotarod software and set start settings to 4 rpm, acceleration settings to 5 min, and final speed settings to 40 rpm. These settings provide a constant acceleration from 4–40 rpm over a period of 5 min. Mice can remain on the rotar....