Antibiotic Bone Cement
Antibiotic Bone Cement - Related Videos
13:39
Antibiotic Susceptibility Testing: Epsilometer Tests to Determine MIC Values of Two Antibiotics and Evaluate Antibiotic Synergy
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2023
Source: Anna Bläckberg1, Rolf Lood1 1 Department of Clinical Sciences Lund, Division of Infection Medicine, Biomedical Center, Lund University, 221 00 Lund Sweden Knowledge of the interactions between antibiotics and bacteria is important in understanding how microbes evolve antibiotic resistance. In 1928, Alexander Fleming discovered penicillin, an antibiotic that exerts its antibacterial function by interfering with cell wall regeneration (1). Other antibiotics with diverse mechanisms of...
01:24
Hydration of Cement
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2024
Hydration of cement is a chemical reaction between cement particles and water. This process occurs primarily through two mechanisms: through-solution and topochemical. In the through-solution process, anhydrous compounds dissolve into their constituents, hydrates form in the solution, and then precipitate from the supersaturated solution. The topochemical process involves solid-state reactions at the cement particle surface. The through-solution process dominates the topochemical process at the...
01:17
Soundness of Cement
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2024
The soundness of cement refers to the ability of cement paste to retain its volume after setting. Unsound cement can lead to expansion and structural damage due to the presence of free lime, magnesia, and calcium sulfate. Free lime hydrates very slowly, expanding and causing unsoundness, which is difficult to detect because it intercrystallizes with other compounds. Magnesia also reacts with water, forming crystals that can disrupt the cement's structure. Calcium sulfate can create ettringite,...
07:42
Detecting the Water-soluble Chloride Distribution of Cement Paste in a High-precision Way
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Cited by 3 •
2017
A protocol for obtaining a water-soluble chloride profile by using a high precision milling method is presented.
01:21
Portland Cement
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2024
Portland cement is the essential binding ingredient in concrete, made from finely ground materials including lime, iron, silica, and alumina. Lime is derived primarily from limestone, marble, marl, seashells, and clays, which also supply iron and alumina, while silica is sourced from sand, chalk, and bauxite. Contemporary manufacturing of Portland cement is a significant source of carbon dioxide emissions, prompting research into reducing its content in concrete through alternative...
FAQs
Drug elution begins when fluid penetrates the hardened cement. That fluid moves through interconnected pores and carries the incorporated antibiotic outward, creating localized antimicrobial exposure near the implant. The extent and persistence of release therefore depend on how the cement’s pore structure and formulation permit fluid access and drug movement.
Antibiotic compatibility, cement formulation, porosity, and mechanical strength all influence performance. Greater attention to porosity and formulation can affect how readily fluid reaches the drug, while structural strength determines whether the cement can continue supporting fixation. Effective design therefore requires balancing antimicrobial elution with the durability needed for implant stabilization.
The antimicrobial component cannot be considered separately from the cement matrix. Compatibility affects whether the formulation can provide the intended local drug release, while changes related to the incorporated drug may be weighed against mechanical requirements. This relationship matters because infection control and implant fixation must be achieved by the same implanted material.
During preparation, the antibiotic is mixed into the cement powder before polymerization. The mixture then polymerizes into a hardened material that can be implanted to provide fixation and local infection control. This sequence is important because drug incorporation occurs before the cement develops its final structure and interconnected pore network.
Its orthopedic uses include joint replacement, revision surgery, and treatment of infected implants. The approach is particularly relevant when a high antibiotic concentration is needed locally at the surgical site while the cement also contributes mechanical fixation. These applications connect infection management with the structural demands of implant-related procedures.
Assessment should consider both local antimicrobial delivery and mechanical performance. Useful questions include whether the formulation supports the needed drug elution, whether its porosity permits fluid-mediated release, and whether the cement retains adequate strength for fixation. A favorable result requires structural durability without losing the intended local infection-control function.