Endometriosis Excision

Endometriosis excision is a surgical treatment that removes endometriotic lesions, or tissue resembling the uterine lining, from sites outside the uterus. Usually performed through minimally invasive laparoscopy, the procedure identifies implants and cuts them out at their visible boundaries, while aiming to preserve surrounding organs and healthy tissue. Excision can provide tissue for histopathological confirmation and may reduce pelvic pain, inflammation, and lesion-related anatomical distortion. In medicine, it supports the management of superficial and deep endometriosis, including disease affecting the ovaries, pelvic peritoneum, or adjacent structures, although treatment planning depends on lesion location, symptoms, reproductive goals, and surgical risk.

Endometriosis Excision - Related Videos

Research

JoVE Journal - Medicine

Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue

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Cited by 62 •

2012

A description of the surgical induction of endometriosis in mice and rats by auto-transplantation of uterine tissue to the arterial cascade of the intestinal mesentery.

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

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Cited by 21 •

2012

Loss of peritoneal integrity provides a new paradigm to understand and treat chronic pelvic pain in women with mild forms of endometriosis and can be easily detected using intraoperative instillation of dye at the time of laparoscopy.

Education

JoVE Core - Molecular Biology
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Base Excision Repair

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2020

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template. The first step of...

Education

JoVE Core - Molecular Biology
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Nucleotide Excision Repair

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2020

Exposure to mutagens can damage DNA and result in bulky lesions that distort the double-helix structure or impede proper transcription. Damaged DNA can be detected and repaired in a process called nucleotide excision repair (NER). NER employs a set of specialized proteins that first scan DNA to detect a damaged region. Next, NER proteins separate the strands and excise the damaged area. Finally, they coordinate the replacement with new, matching nucleotides.DNA distortion and damageCells are...

Education

JoVE Core - Cell Biology
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Nucleotide Excision Repair

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2023

DNA Distortion and Damage Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...

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