Selective Lesion Induction
Selective Lesion Induction - Related Videos
11:33
Inductance
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2023
Source: Yong P. Chen, PhD, Department of Physics & Astronomy, College of Science, Purdue University, West Lafayette, IN This experiment will use inductive coils to demonstrate the concept of inductor and inductance. Magnetic induction will be demonstrated using a rod magnet inserted into or extracted away from the core of a coil to induce a transient electromotive force (emf) voltage in the coil, measured by a voltmeter. This experiment will also demonstrate the mutual inductance between...
08:16
Comparative Lesions Analysis Through a Targeted Sequencing Approach
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2019
This article describes a method to identify clonal and subclonal alterations among different specimens from a given patient. Although the experiments described here focus on a specific tumor type, the approach is broadly applicable to other solid tumors.
09:22
Sectioning Mammary Gland Whole Mounts for Lesion Identification
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Cited by 13 •
2017
We developed a method to successfully remove, process, section, and stain, for histopathological evaluation, mammary tissue that had originally been fixed on slides as whole mounts. This method may promote the collection and evaluation of mammary gland whole mounts in reproductive and developmental test guideline studies.
14:01
Anesthesia Induction and Maintenance
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2016
Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN The Guide for the Care and Use of Laboratory Animals ("The Guide") states that pain assessment and alleviation are integral components of the veterinary care of laboratory animals. The definition of anesthesia is the loss of feeling or sensation. It is a dynamic event involving changes in anesthetic depth with respect to an animal's metabolism, surgical stimulation, or variations in the...
11:18
AC Induction Motor Characterization
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2023
Source: Ali Bazzi, Department of Electrical Engineering, University of Connecticut, Storrs, CT. The objectives of this experiment are to find the equivalent circuit parameters of a three-phase induction motor using the per-phase equivalent circuit and tests similar to those used in transformer characterization. In electrical engineering, an equivalent circuit (or theoretical circuit) can be determined for a given system. The equivalent circuit retains all characteristics of the original system,...
FAQs
Selectivity depends on matching the injury method to a defined tissue or cell population and confining the intervention to its intended site. Stereotaxic delivery, focal ablation, and controlled physical injury do not necessarily disrupt the same structures. Consequently, the selected approach shapes both the cellular pattern of damage and the reliability of conclusions drawn from the resulting model.
These approaches differ mainly in how the target is reached and how the lesion is confined. Stereotaxic delivery places an excitotoxic or neurotoxic agent at a selected site, whereas focal ablation and controlled physical injury use other forms of localized disruption. Comparing them helps investigators choose a model suited to the tissue, cells, and functional question under study.
Minimizing collateral damage makes it easier to associate an observed change with the intended tissue or cell population rather than with injury elsewhere. This improves interpretation of anatomical, physiological, behavioral, or clinical findings. The more clearly the affected site is separated from surrounding structures, the more confidently investigators can study relationships between localized damage and function.
The target site, the population selected for disruption, and the injury approach all influence the resulting model. A stereotaxic agent delivery, focal ablation, or controlled physical injury can produce different patterns of tissue disruption and spatial confinement. These differences affect whether the experiment best reveals anatomical organization, physiological consequences, behavioral effects, or clinical function.
A study begins by defining the tissue or cell population to be examined, then selecting an approach that can reach and disrupt that target while limiting effects on nearby structures. Investigators may use stereotaxic delivery, focal ablation, or controlled physical injury. They subsequently examine changes in anatomy, physiology, behavior, or clinical function to evaluate the model.
Post-lesion analysis can connect tissue damage with changes across several levels of function. Anatomical observations show where disruption occurred, while physiological, behavioral, or clinical assessments reveal consequences for system operation. Taken together, these outcomes help researchers infer the contribution of the affected tissue or cells and evaluate how localized injury alters function.
This approach supports investigations of disease mechanisms, nervous-system organization, therapeutic strategies, and tissue repair. By creating a defined injury model, researchers can examine how damage changes structure and function, then use those observations to study potential interventions or recovery processes. Its value lies in connecting a localized tissue disturbance with broader medical or biological outcomes.
In nervous-system research, targeting a defined region or cell population allows investigators to relate localized disruption to changes in physiology, behavior, or clinical function. Stereotaxic delivery of an excitotoxic or neurotoxic agent is one supported route for establishing such models. These experiments can clarify how particular structures contribute to nervous-system organization and function.