Journal
/
의학
/
Intranasal Administration of CNS Therapeutics to Awake Mice
JoVE 신문
의학
JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다.  전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
JoVE 신문 의학
Intranasal Administration of CNS Therapeutics to Awake Mice

Intranasal Administration of CNS Therapeutics to Awake Mice

57,696 Views

•

07:15 min

•

April 08, 2013

DOI:

10.3791/4440-v

DOI:
10.3791/4440-v

•

07:15 min
April 08, 2013

•

107 Views
, , ,
1Alzheimer’s Research Center at Region’s Hospital,HealthPartners Institute for Education and Research

Summary

Automatically generated

A method to intranasally administer drugs to awake mice for the purpose of targeting the brain is described. This method allows for repeat dosing over long periods using intranasal administration of drug without anesthesia, and nose-to-brain delivery with minimal systemic exposure.

Explore More Videos

Intranasal AdministrationCNS TherapeuticsAwake MiceNon-invasive DeliveryBlood-brain BarrierTargeted Drug DeliverySystemic ExposureIntranasal Delivery In Clinical TrialsPharmacokinetic DistributionEfficacy EvaluationAwake Delivery In MiceChronic Dosing Without AnesthesiaIntranasal Grip For Mice

Read Article

Cite this Article

Hanson, L. R., Fine, J. M., Svitak, A. L., Faltesek, K. A. Intranasal Administration of CNS Therapeutics to Awake Mice. J. Vis. Exp. (74), e4440, doi:10.3791/4440 (2013).

Download .ris file

Copy

Share Video

.

Copy