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Particles without a Box: Brush-first Synthesis of Photodegradable PEG Star Polymers under Ambient Conditions

Article DOI: 10.3791/50874-v • 06:56 min • October 10th, 2013
October 10th, 2013 •
1, 1, 1
1Department of Chemistry, Massachusetts Institute of Technology

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Poly(ethylene glycol) (PEG) brush-arm star polymers (BASPs) with narrow mass distributions and tunable nanoscopic sizes are synthesized in via ring opening metathesis polymerization (ROMP) of a PEG-norbornene macromonomer followed by transfer of portions of the resulting living brush initiator to vials containing varied amounts of a rigid, photo-cleavable bis-norbornene crosslinker.

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Particles Box Brush-first Synthesis Photodegradable PEG Star Polymers Ambient Conditions Rapid Synthesis Diversely Functionalized Nanoparticles Drug Delivery Biological Imaging Supported Catalysis Brush-arm Star Polymer BASP Nanoparticles Norbornene-terminated Poly(ethylene Glycol) PEG Macromonomer Ring-opening Metathesis Polymerization ROMP Living Brush Macroinitiator Photodegradable Bis-norbornene Crosslinker Kinetically-controlled Reactions BASP Cores And Coronas Crosslinker Amount Benchtop Synthesis Air And Moisture Removal Precautions Gel Permeation Chromatography Practical Features Advantages And Potential Disadvantages
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