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JoVE Journal Chemistry
Amid Kobling Reaktion for syntesen af ​​bispyridin-baserede ligander og deres kompleksdannelse til Platinum som bicycliske anticancerlægemidler
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Amid Kobling Reaktion for syntesen af ​​bispyridin-baserede ligander og deres kompleksdannelse til Platinum som bicycliske anticancerlægemidler

Article DOI: 10.3791/51740-v • 07:20 min • May 28th, 2014
May 28th, 2014 •
1, 2, 3, 4, 1
1Faculty of Pharmacy, The University of Sydney, 2School of Science and Health, University of Western Sydney, 3Division of Chemistry and Environmental Science, School of Science and the Environment, Manchester Metropolitan University, 4Nature Publishing Group

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Denne protokol beskriver anvendelsen af ​​amidkobling reaktioner isonikotinsyre og diaminoalkaner til dannelse brodannende ligander egnede til anvendelse i syntesen af ​​multinucleare platinkomplekser, der kombinerer aspekter af anticancerlægemidler BBR3464 og picoplatin.

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Kemi BBR3464 picoplatin bispyridin amid kobling uorganisk syntese kræft
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