Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Choong Yong Ung; Feng Guo; Xiaoling Zhang; Zhihui Zhu; Shizhen Zhu

doi:10.3791/52567

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종양의 병인에 후보 협동 유전자의 기능 게놈 분석을위한 모자이크 Zebrafish의 Transgenesis

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

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Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

종양의 병인에 후보 협동 유전자의 기능 게놈 분석을위한 모자이크 Zebrafish의 Transgenesis

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11,082 Views

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09:45 min

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March 31, 2015

DOI:

10.3791/52567-v

DOI:

10.3791/52567-v

•

09:45 min

March 31, 2015

•

4 Views

Choong Yong Ung¹, Feng Guo², Xiaoling Zhang³, Zhihui Zhu³, Shizhen Zhu^1,3

¹Department of Molecular Pharmacology & Experimental Therapeutics,Mayo Clinic College of Medicine, Center for Individualized Medicine, ²Tufts University School of Medicine, ³Department of Biochemistry and Molecular Biology,Mayo Clinic

Summary

The goal of this study is to demonstrate how the mosaic transgenesis strategy can be used in zebrafish to rapidly and efficiently assess the relative contributions of multiple oncogenes in tumor initiation and progression in vivo.

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종양의 병인에 후보 협동 유전자의 기능 게놈 분석을위한 모자이크 Zebrafish의 Transgenesis

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