Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Pengju Feng; Ming-Yu Ngai

doi:10.3791/53789

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화학

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의 합성을위한 프로토콜 직교 -trifluoromethoxylated 아닐린 파생 상품

Protocol for the Synthesis of <em>Ortho</em>-trifluoromethoxylated Aniline Derivatives

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JoVE 신문 화학

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

의 합성을위한 프로토콜 직교 -trifluoromethoxylated 아닐린 파생 상품

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9,908 Views

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08:43 min

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January 19, 2016

DOI:

10.3791/53789-v

DOI:

10.3791/53789-v

•

08:43 min

January 19, 2016

•

4 Views

Pengju Feng^1,2, Ming-Yu Ngai^1,2

¹Department of Chemistry,State University of New York at Stony Brook, ²Institute of Chemical Biology and Drug Discovery,State University of New York at Stony Brook

내레이션 대본

Summary

An operationally simple procedure for the synthesis of ortho-trifluoromethoxylated aniline derivatives via a two-step sequence of O-trifluoromethylation of N-aryl-N-hydroxyacetamide followed by thermally induced intramolecular OCF₃-migration is reported.