Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Mianbo Huang; Jin Xu; Chong Hyun Shin

doi:10.3791/54002

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Zebrafish의에서 에탄올에 의한 섬유 성 간 모델의 개발은 전구 세포 매개 간세포의 재생을 연구하는

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

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Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Zebrafish의에서 에탄올에 의한 섬유 성 간 모델의 개발은 전구 세포 매개 간세포의 재생을 연구하는

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9,113 Views

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10:42 min

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May 13, 2016

DOI:

10.3791/54002-v

DOI:

10.3791/54002-v

•

10:42 min

May 13, 2016

•

6 Views

Mianbo Huang¹, Jin Xu¹, Chong Hyun Shin¹

¹School of Biology, Parker H. Petit Institute for Bioengineering and Bioscience,Georgia Institute of Technology

내레이션 대본

Summary

Sustained fibrosis with deposition of excessive extracellular matrix proteins leads to cirrhosis. Alcohol abuse is one of the main causes of severe liver disease. We established an ethanol-induced zebrafish fibrotic liver model to study the mechanisms and strategies of promoting hepatocyte regeneration upon alcohol-induced injury.