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Automatiserad Contraction analys av Human Engineered hjärtvävnad för Cardiac Drug Safety Screening

Article DOI: 10.3791/55461-v • 10:39 min • April 15th, 2017
April 15th, 2017 •
1, 1, 1, 1, 1, 1, 1
1Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf and DZHK (German Center for Cardiovascular Research)

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Här visar vi generering av human engineered hjärtvävnad från inducerade pluripotenta stamceller (hiPSC) -härledda kardiomyocyter. Vi presenterar en metod för att analysera kontraktionskraften och exemplarisk förändring av kontraktion mönster av hERG-kanal-inhibitorn E-4031. Denna metod visar hög nivå av robusthet och lämplighet för hjärtläkemedelsscreening.

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Bioteknik Engineered hjärtvävnad kardiomyocyter vävnadsteknik hjärtdifferentiering läkemedelssäkerhet farmakologi
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