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Bioengineering

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JoVE Journal Bioengineering
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Preclinical Drug Testing in Scalable 3D Engineered Muscle Tissues

Article DOI: 10.3791/64399-v • 08:07 min • April 7th, 2023
April 7th, 2023 •
*1, *1, 1, 1, 1, 1, 1, 1, 1, 1
1Curi Bio Inc.
* These authors contributed equally

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Summary
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This protocol provides methods for generating 3D engineered cardiac and skeletal muscle tissues and describes their use in preclinical drug screening modalities. The described methods utilize a magnetic sensing system to facilitate the simultaneous assessment of 24 tissues in parallel.

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Preclinical Drug Testing Scalable 3D Engineered Muscle Tissues Magnetic Sensing Hardware Contractility Measurement Higher Throughput Method In Vitro Assessment Human Muscle Tissues Casting Method Consistency And Reproducibility 24-well Casting Plate Consumable Contractility Measurements In Vitro Disease Modeling Drug Discovery Gene Therapy Muscle Disease Motor Neurons Neuromuscular Junction Model Pre-chilled Tissue Casting Kit Thrombin Solution RPMI Medium B27 Aminocaproic Acid (ACA) Cardiac EMT Medium
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