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Partiell ischiasnervligering: En musmodell av kronisk neuropatisk smärta för att studera den antinociceptiva effekten av nya terapier

Article DOI: 10.3791/64555-v • 08:16 min • October 6th, 2022
October 6th, 2022 •
1, 1, 2, 1, 1, 5, *1,2,3,4, *1,2
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, 2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, 3Neuroscience Graduate Interdisciplinary Program, College of Medicine, The University of Arizona, Tucson, 4Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, 5Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center
* These authors contributed equally

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Partiell ischiasnervligering inducerar långvarig kronisk neuropatisk smärta, kännetecknad av överdrivna svar på termiska och mekaniska stimuli. Denna musmodell av neuropatisk smärta används ofta för att studera innovativa terapier för smärtlindring. Denna artikel beskriver i detalj det kirurgiska ingreppet för att förbättra standardisering och reproducerbarhet.

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