Limit of Detection and Quantification

The limit of detection, or LOD, is the smallest amount of analyte that can be distinguished from background noise. In measurement science, background noise is the natural signal in a sample that can interfere with the analyte signal. The LOD helps show whether a substance is present, but it does not usually give a reliable a...

Background noise is intrinsic to any measurement interfering with the detection of the analyte signal. To analyze if the measured signal is from the analyte or only noise, the limit of detection is calculated.

The limit of detection is the lowest quantity of analyte detected, whose signal is distinct from the background noise. The LOD is ...