3.13
Compartimentmodellen: Een compartimentmodel met één compartiment
Het compartimentmodel met één compartiment dient als een vereenvoudigde representatie van het menselijk lichaam. Dit model veronderstelt dat het licha…
The single-compartment model assumes the human body is a single well-stirred open compartment.
When a drug administered through IV bolus enters the body, it distributes instantaneously without barriers and leaves the body through biotransformation and elimination.
The volume of the compartment is the apparent volume of distribution—a theoretical volume that the administered dose can rapidly and uniformly distribute into.
Drug clearance from the body follows first-order kinetics, where the elimination rate is directly proportional to the drug concentration in the body.
With time, drug plasma concentration declines exponentially with a proportional decline in the tissue drug concentration.
A continuous infusion of a given dose attains a steady-state value exponentially. If infusion stops, the concentration falls exponentially.
If the same dose is administered in multiple equal doses, the mean steady-state concentration and the time required to reach the steady state are similar to that of a continuous infusion.
View the full transcript and gain access to JoVE Core videos
Q1: What is the single-compartment model in pharmacokinetics?
The single-compartment model represents the human body as a single well-stirred open compartment where drugs distribute instantaneously without barriers. When administered intravenously, a drug rapidly distributes uniformly throughout this compartment and then undergoes biotransformation and elimination. This simplified model assumes uniform drug concentration across the body at any given time.
Q2: How does drug clearance work in the single-compartment model?
Drug clearance from the body follows first-order kinetics, meaning the elimination rate is directly proportional to the drug concentration present. As concentration decreases, the elimination rate also decreases proportionally. This results in exponential decline of both plasma and tissue drug concentrations over time, following drug elimination the concept of clearance.
Q3: What is the apparent volume of distribution?
The apparent volume of distribution is a theoretical volume into which an administered drug dose can rapidly and uniformly distribute within the single-compartment model. It represents the relationship between the amount of drug in the body and its plasma concentration. This volume helps predict how extensively a drug distributes throughout the body.
Q4: How does continuous infusion reach steady state in the single-compartment model?
During continuous infusion, drug concentration rises exponentially until reaching a steady-state value where the infusion rate equals the elimination rate. Once steady state is achieved, plasma concentration remains constant. If infusion stops, the concentration falls exponentially following first-order kinetics throughout the body.
Q5: How do multiple equal doses compare to continuous infusion?
When a drug is administered in multiple equal doses, the mean steady-state concentration and time required to reach steady state are similar to those achieved with continuous infusion. Both dosing approaches result in comparable pharmacokinetic profiles, though multiple dosing creates fluctuations around the mean concentration value.
Q6: Why is the single-compartment model considered a simplified representation?
The single-compartment model assumes the body functions as one well-mixed compartment with instantaneous, uniform drug distribution and no physiological barriers. In reality, drugs distribute at different rates into various tissues and organs. This simplification makes calculations manageable for basic pharmacokinetic predictions while acknowledging limitations.
Q7: What happens to drug concentration after an IV bolus in the single-compartment model?
After intravenous bolus administration, the drug distributes instantaneously and uniformly throughout the compartment. Plasma concentration then declines exponentially as the drug undergoes biotransformation and elimination. The tissue drug concentration follows a similar exponential decline pattern proportional to the plasma concentration changes.