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Most drugs are administered in multiple fixed doses repeated at defined intervals to achieve and maintain safe and therapeutic levels of the drug in the body.
Such fixed-dose regimens can be followed for both intravenous and oral medications. For example, one unit of a drug can be injected twice daily, or a pill can be taken three times a day.
When the first dose of a drug is administered, its plasma concentration peaks and then starts declining due to elimination. As the concentration falls to 50% of the starting value, the next dose is administered to raise the drug's plasma levels again.
Such a repetitive dosage cycle allows the body to accumulate the drug until a steady state is achieved, where the rate of administration becomes the same as the elimination rate.
A well-designed fixed dosage regimen avoids excessive fluctuations of drug concentrations, remaining within a safe therapeutic range to generate an effective and lasting response.
Vaste doseringsschema's zijn een veelgebruikte benadering om geneesmiddelen toe te dienen om gewenste niveaus van het geneesmiddel in het lichaam te b…
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