Barrett-slokdarm I: Inleiding

Barrett's esophagus is characterized by severe damage to the mucosal lining due to persistent exposure to stomach acid or other digestive fluids.

The primary cause of Barrett's esophagus is gastroesophageal reflux disease.

This chronic condition occurs when the lower esophageal sphincter, a high-pressure zone at the esophagus-stomach junction, weakens or relaxes abnormally, allowing stomach acid to flow back into the esophagus.

Prolonged exposure to stomach acid can cause metaplasia, where the pink mucosal lining of the lower esophagus transforms into a simple columnar epithelium similar to that found in the intestines.

In Barrett's esophagus, tissue cells may undergo dysplasia, an abnormal growth that progresses through several stages.

These stages include non-dysplastic initial cell changes, low-grade dysplasia characterized by mild abnormal growth, high-grade dysplasia with severe abnormalities and a high cancer risk, and finally, adenocarcinoma, which is the formation of cancer.

Other risk factors for Barrett's esophagus include obesity, smoking, and alcohol consumption.