Model met één compartiment: IV-infusie

IV infusion is suitable when maintenance of constant and stable drug concentration in the body is desired or when the drug poses toxicity risks.

For instance, IV infusion is used for antibiotics, where dosage control is critical.

In a one-compartment model, the rate of change in the amount of drug in the body equals the difference between the infusion and elimination rates, mathematically represented by the given equations.

The steady-state or infusion equilibrium is achieved when the rate of drug infusion equals its elimination rate.

The elimination rate constant, a crucial pharmacokinetic parameter, can be determined from the semilog plasma concentration-time plot, by calculating the slope of the line.

The apparent volume of distribution and total systemic clearance, two critical pharmacokinetic metrics, can be estimated using the steady-state concentration and the infusion rate.

They can also be computed from the total area under the curve until the end of infusion.