Open model met één compartiment voor extravasculaire toediening: absorptiemodel van de eerste orde

The first-order absorption model for extravascular administration considers the rate at which a drug is absorbed, distributed in body tissues, and eliminated to follow first-order kinetics.

This model provides a mathematical representation of drug absorption and elimination. It helps predict and interpret drug behavior within the body.

Here, the rate of change in drug concentration over time can be expressed using mathematical equations.

Vital pharmacokinetic parameters can be calculated, including peak plasma concentration and the time taken to reach it.

The absorption rate constant can be determined using the method of residuals or Wagner-Nelson method.

This model can be illustrated as a plasma drug concentration-time profile consisting of absorption and elimination phases.

The plasma drug concentration-time curve may exhibit the flip-flop phenomenon, where the meanings of the slopes representing absorption and elimination interchange.

The lag time signifies the delay between drug administration and the initiation of absorption.