Modelbenaderingen voor farmacokinetische gegevens: fysiologische modellen

Physiological models illustrate the drug's distribution and elimination processes within the body.

They describe the drug concentration in target organs, influenced by drug uptake, tissue volume, and blood flow.

Drug uptake is governed by the partition coefficient, symbolizing the drug concentration ratio in tissue to that in the blood.

The blood flow rate to a specific tissue is expressed as Q_t. The rate of change in tissue drug concentration can be expressed mathematically, with C_art and C_ven as the arterial and venous blood drug concentrations, respectively.

Physiological models can be categorized into blood flow-limited models and diffusion-limited models.

In a blood flow-limited model, drug distribution is primarily regulated by the blood flow to the tissue.

Conversely, in a diffusion-limited model, the diffusion rate across tissue barriers predominantly controls drug distribution.

Physiological models are crucial in pharmacokinetics, enhancing the understanding of complex drug interactions within the body.