Niet-lineaire farmacokinetiek: eliminatie van geneesmiddelen voor intraveneuze bolusinjectie

In capacity-limited pharmacokinetics, drug elimination is influenced by V_max and K_M.

Following an IV bolus, D_t, the amount of drug in the body at any given time can be calculated.

The equation can be rearranged to determine the time required for the drug concentration to decline to a specific amount.

For instance, consider a drug at a specific dose with constant K_M and variable V_max. As an inverse relationship exists between the time for the drug concentration to decline and V_max, a higher V_max requires less time for the drug concentration to decline than a lower V_max.

Now, consider a drug at a constant V_max and variable K_M. Since a direct relationship exists between the time for the drug concentration to decline and K_M, higher K_M leads to a longer elimination time for the drug compared to the one with lower K_M.