Therapeutische geneesmiddelmonitoring: overzicht en classificatie

Therapeutic drug monitoring, or TDM, involves consistent patient monitoring to ensure that drug levels in the blood are within a safe and effective range.

It optimizes individual dosage and enhances therapeutic efficacy while reducing medical costs.

TDM helps prevent serious side effects for drugs with narrow therapeutic windows, such as warfarin and gentamicin, ensuring patient safety.

For instance, it helps prevent phenytoin toxicity in chronic epilepsy and balances effectiveness against potential harm in high-dose agents like methotrexate for cancer treatment.

TDM also supports personalized medicine by adjusting dosages based on individual metabolic responses and interactions with other medications.

TDM can be categorized into 3 types: therapeutic monitoring, which assesses the incidence and intensity of desired and undesired drug effects; pharmacodynamic monitoring, which focuses on the drug's pharmacological actions; and pharmacokinetic monitoring, which involves measuring plasma drug concentrations.