Farmacodynamische modellen: additief en proportioneel geneesmiddeleffectmodel

Typically, a baseline response exists even without drug administration.

Drug response models describe how this baseline combines with the drug’s effect, either in an additive or proportional manner.

In the additive model, the total observed response, R(t), is the sum of the baseline response, R(0), and the total drug effect, E. The total effect, E, can follow a linear or E_max-type relationship.

For stimulatory drugs such as argatroban, the plasma concentration-response curve often shows a sigmoidal increase, especially in E_max models.

Now, consider the baseline response in the proportional drug effect model. In this model, the drug amplifies or diminishes the baseline response.

The total effect may also follow a linear or E_max-type relationship.

In this model, the response depends on the baseline value, with a steeper decrease seen for the largest baseline compared to smaller baselines.