Method Article

Het combineren van meerdere Data Acquisition Systems corticospinale Output en Multi-segment biomechanica Studie

DOI:

10.3791/53492

⸱

January 9th, 2016

 ,  ,  ,  ,  , 
1Department of Kinesiology, McMaster University, 22Els Espots

In This Article

Summary

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The use of transcranial magnetic stimulation (TMS) to study human motor control requires the integration of data acquisition systems to control TMS delivery and simultaneously record human behavior. The present manuscript provides a detailed methodology for integrating data acquisition systems for the purpose of investigating human movement via TMS.

Abstract

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Transcranial magnetic stimulation techniques allow for an in-depth investigation into the neural mechanisms that underpin human behavior. To date, the use of TMS to study human movement, has been limited by the challenges related to precisely timing the delivery of TMS to features of the unfolding movement and, also, by accurately characterizing kinematics and kinetics. To overcome these technical challenges, TMS delivery and acquisition systems should be integrated with an online motion tracking system. The present manuscript details technical innovations that integrate multiple acquisition systems to facilitate and advance the use of TMS to study human movement. Using commercially available software and hardware systems, a step-by-step approach to both the hardware assembly and the software scripts necessary to perform TMS studies triggered by specific features of a movement is provided. The approach is focused on the study of upper limb, planar, multi-joint reaching movements. However, the same integrative system is amenable to a multitude of sophisticated studies of human motor control.

Introduction

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Transcraniële magnetische stimulatie (TMS) is een niet-invasieve methode voor het menselijke cortex stimuleren. 3,5 Er zijn verschillende TMS protocollen die worden gebruikt voor corticale functies begrijpen zoals enkelvoudige en meervoudige pulsen, dual-ter stimulatie functionele connectiviteit sonde en herhalende pulsen om neurale plasticiteit te promoten. 4,6-8 TMS protocollen kunnen ook worden gecombineerd om de huidige begrip van de menselijke corticale processen te bevorderen en te begeleiden neurale revalidatie strategieën. Naast het stimuleren van de cortex, TMS kan ook worden gebruikt om sub-corticale functie begrijpen door stimulatie v....

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Protocol

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OPMERKING: Het volgende protocol kan worden toegepast op een verscheidenheid van experimenten. Hieronder vindt u meer informatie over een experiment dat een visueel geleide arm bereiken taak om een ​​van de zes ruimtelijke doelen weergegeven op een computer monitor gaat. TMS, te corticospinale prikkelbaarheid sonde, wordt veroorzaakt door een van beide analoge signalen die uit de beweging (dwz, EMG of electrogoniometer input) of digitale signalen gegenereerd uit de sweep gebaseerde data acquisitie software. Dit onderzoek is in overeenstemming met de Verklaring van Helsinki van de McMaster Research Ethics Board goedgekeurd. Een voorbeeld dataset wordt verstre....

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Results

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Figuur 3 toont de resultaten van een proef. In dit proces, Figuur 3A toont de uitgangspositie van de deelnemer en na een auditieve 'go' cue, de deelnemer bewoog zo snel en nauwkeurig mogelijk het doelwit (bijv., De eindpositie). De sweep-gebaseerde data-acquisitie software leidde tot een TMS puls gebaseerd op EMG onset in de biceps brachii spier. Hierdoor kon de mate van corticospinale uitvoer gericht op bovenarm spieren worden geëvaluee.......

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Discussion

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The present manuscript details an innovative method to integrate TMS and motion capture systems in the context of a visuo-motor task. To make rapid and meaningful advances in the study of human motor control, it is essential that methodologies allow for precise communication across multiple hardware and software systems. The paradigm presented could be used to study a variety of research interests including the cortical contribution to motor learning, the neurophysiology of motor control, and multi-joint movement contr.......

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Disclosures

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The authors have nothing to disclose.

Acknowledgements

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The authors thank funding from the Natural Sciences and Engineering Research Council to AJN.

....

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Materials

List of materials used in this article
NameCompanyCatalog NumberComments
Polhemus FASTRAKPolhemus Inc.6 degrees of freedom electromagnetic motion tracking device with 4 sensors
PresentationNeurobehavioural Systems Inc.A fully programmable software for experiments involving data acquisition and stimulus delivery
Cutom built Exoskeleton80/20 Inc. - The industrial erector setVariesVarious parts used to build the exoskeleton
BrainsightRogue Research Inc.Neuronavigation software to track coil position throughout the experiment

References

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  1. Chen, R., Yung, D., Li, J. Y. Organization of ipsilateral excitatory and inhibitory pathways in the human motor cortex. J Neurophysiol. 89 (3), 1256-1264 (2003).
  2. Criswell, E. Cram's Introduction to Surface Electromyorgaphy. , 2nd edn, Jones and Barlett Publishers. Mississauga, Canada. (2011).
  3. Di Lazzaro, V., et al.

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Tags

Transcranial Magnetic StimulationMotor Evoked PotentialElectromyography SignalMotion Tracking SystemCorticospinal OutputUpper Limb MovementJoint Angle AnalysisKinematic Kinetic AnalysisData Acquisition IntegrationNeuromotor Control Study

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