Plga Peg Copolymer
Plga Peg Copolymer - Related Videos
10:53
Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
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Cited by 2 •
2016
The key steps of living anionic polymerization of phenyl glycidyl ether (PheGE) on methoxy-polyethylene glycol (mPEG-b-PPheGE) are described. The resulting block copolymer micelles (BCMs) were loaded with doxorubicin 14% (wt%) and sustained release of drug over 4 days under physiologically relevant conditions was obtained.
07:50
Electrophysiology of Scorpion Peg Sensilla
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Cited by 4 •
2011
This article describes an electrophysiological method for isolating chemical stimulation to individual sensilla via extracellular, tip-recordings under mineral oil.
09:15
Synthesis of Ligand-free CdS Nanoparticles within a Sulfur Copolymer Matrix
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2016
Herein we present a method to synthesize ligand-free cadmium sulfide (CdS) nanoparticles based on a unique sulfur copolymer. The sulfur copolymer operates as a high temperature solvent and a sulfur source during the nanoparticle synthesis and stabilizes the nanoparticles after the reaction.
06:41
A Peg Plate Biofilm Assay for Screening Antibacterial Agents
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2025
This video demonstrates an assay for screening antimicrobial compounds that efficiently eliminate biofilms using a peg-plate. The methodology monitors the biofilm's metabolic state after treatment with antimicrobial compounds, facilitating the determination of the minimum biofilm eradication concentration.
12:48
PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
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Cited by 211 •
2013
We describe the production and characterization of nanoparticles and microparticles composed of poly(lactic-co-glycolic acid) using vitamin E-TPGS as an emulsifier. By varying formulation parameters such as the concentration of emulsifier, it is possible to produce nanoparticles with mean diameters ranging from 220 nm to 1.98 µm.
FAQs
The two blocks contribute contrasting water interactions: PLGA provides the degradable segment, whereas PEG remains hydrophilic and water-compatible. In an aqueous environment, this contrast supports organization into structures such as micelles and nanoparticles, with PEG associated with the hydrated exterior. The resulting arrangement helps create dispersed carriers for incorporating cargo.
Changing the relative amounts of PLGA and PEG alters the balance between degradability, aqueous dispersion, particle stability, and cargo release. A composition with more influence from one block can therefore produce a different structural or release profile than another. Researchers use this tunability to match the copolymer architecture to a particular bioengineering objective.
PLGA segments hydrolyze into lactic acid and glycolic acid, progressively changing the material as degradation occurs. That transformation can affect how a loaded compound is retained and released from the polymer structure. Because block composition and architecture influence degradation behavior, they also provide ways to tune release rather than treating it as a fixed property.
PEG forms a hydrated outer layer that improves compatibility with aqueous environments and can reduce nonspecific interactions. This interfacial effect supports dispersion of assembled structures and may help maintain their usefulness in biological settings. Its contribution is distinct from PLGA degradation, so adjusting both blocks allows researchers to balance surface behavior with internal material breakdown.
Their self-assembly can create carriers that encapsulate compounds with limited water solubility while presenting PEG at the aqueous interface. This combination addresses two design needs at once: incorporating the cargo into a polymer-based structure and maintaining dispersion in water. Such systems are therefore relevant to controlled drug-delivery designs involving poorly water-soluble compounds.
Applications include controlled drug delivery, encapsulation of poorly water-soluble compounds, and engineered biomaterials. The appropriate structure depends on the desired combination of particle stability, degradation, aqueous compatibility, and cargo release. By modifying block composition and architecture, researchers can adapt the same copolymer platform to different delivery or material-engineering requirements.