Thiol-ene Polymer
Thiol-ene Polymer - Related Videos
11:09
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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Cited by 3 •
2018
We present a protocol for the construction of thioether/vinyl sulfide-tethered helical peptides using photo-induced thiol-ene/thiol-yne hydrothiolation.
02:34
Polymers
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2020
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
11:17
Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
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Cited by 107 •
2016
A novel methodology is presented to synthesize and program main-chain liquid-crystalline elastomers using commercially available starting monomers. A wide range of thermomechanical properties was tailored by adjusting the amount of crosslinker, while the actuation performance was dependent on the amount of applied strain during programming.
02:33
Preparation and Reactions of Thiols
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2023
Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol. This reaction fails because the thiol product can undergo a second nucleophilic substitution reaction in the presence of an excess alkyl halide to generate a sulfide as a by-product. This limitation can be overcome by using thiourea as the nucleophile. The reaction first produces an alkyl...
02:17
Structure and Nomenclature of Thiols and Sulfides
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2023
Thiols and sulfides are sulfur analogs of alcohols and ethers, respectively, where the sulfur atom takes the place of the oxygen atom. Thus, thiols are generally represented as RSH, where R is an alkyl substituent and —SH is the functional group. On the other hand, in sulfides, the central sulfur atom is bonded to two hydrocarbon groups on either side. Depending upon the type of group, sulfides can be either symmetrical or asymmetrical. Both thiols and sulfides display a bent geometry, similar...
FAQs
The reaction’s sequence helps explain why these materials can form controlled networks. A light source or another radical source generates thiyl radicals, which add to carbon–carbon double bonds. The resulting radical can abstract hydrogen and continue propagation, producing a step-growth process rather than an uncontrolled chain-growth description. This sequence supports relatively uniform network architectures and tunable material properties.
Thiyl radicals are the key reactive intermediates because they connect alkene addition with continued network formation. After a thiyl radical adds across an alkene double bond, hydrogen abstraction regenerates a radical capable of further propagation. This repeated sequence explains how thiol and alkene functionalities can be consumed efficiently during curing, supporting rapid formation of crosslinked materials.
The step-growth character matters because network formation proceeds through repeated reactions between functional groups rather than relying on a single growing chain. In the described chemistry, this behavior contributes to relatively uniform architectures and gives designers more precise control over network structure and resulting properties. That control is valuable when matching a material to a bioengineering use.
A typical formulation combines thiol-containing molecules with alkene-functionalized molecules and supplies light or another radical source to initiate curing. The activation generates thiyl radicals, while the thiol and alkene functionalities provide the reacting groups that propagate network formation. Because the chemistry can operate under mild conditions, it supports fabrication of hydrogels, scaffolds, and encapsulation matrices.
Thiol-ene polymer networks can serve as hydrogels and three-dimensional scaffolds for tissue engineering. Their modular functionalization and efficient curing provide a basis for designing crosslinked materials with controlled network structures. These features make the chemistry relevant when researchers need biomaterial formats that can be adapted to tissue-engineering objectives while retaining the benefits of rapid network formation.
For controlled delivery and encapsulation, the relevant design features are efficient curing and modular functionalization within a crosslinked matrix. Thiol-ene systems can therefore be considered when a bioengineering study needs a hydrogel or related material to house cells or drugs. Their value lies in linking network design with the intended delivery or biomaterial function.