Pancreatic Function Preservation
Pancreatic Function Preservation - Related Videos
10:10
Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms
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2026
This protocol presents robotic duodenum-preserving total pancreatic head resection (R-DPPHRt) for intraductal papillary mucinous neoplasms (IPMNs). A video demonstrates the technique in a patient with main duct-IPMN, highlighting its feasibility as a minimally invasive, organ-preserving alternative to pancreaticoduodenectomy.
08:54
Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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Cited by 29 •
2015
We describe a method of ex vivo machine perfusion of human liver grafts at subnormothermic temperature (21 °C).
11:54
Human Pancreatic Islet Isolation: Part I: Digestion and Collection of Pancreatic Tissue
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Cited by 20 •
2009
Achieving high quality and appropriate quantity of human islets is one of the prominent prerequisites for successful islet transplantation. In this video, we describe step by step the procedures for human pancreatic islet isolation (part I: digestion and collection of pancreatic tissue) using a modified automated method.
09:12
Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
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Cited by 17 •
2014
One key to successful investigation of microglial biology is the preservation of microglial immunofunction ex vivo during isolation from CNS tissue. Isolating microglia via rotary shaking results in highly pure and immunofunctional cell cultures as assessed by fluorescent imaging, immunocytochemistry, and ELISA following microglia activation with the proinflammatory stimuli lipopolysaccharide (LPS) and Pam3CSK4 (Pam).
03:34
Laparoscopic Duodenum-Preserving Pancreatic Head Resection via Inferior Infracolic Approach: A Surgical Approach for Benign Lesions
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2024
This article provides a whole technical process of laparoscopic duodenum-preserving pancreatic head resection via an inferior infracolic approach. This is a surgical approach for benign tumors without intraoperative fluorescence image guidance.
FAQs
Two functional cell populations require attention: islet cells support insulin production, whereas acinar cells secrete digestive enzymes. Damage to either compartment creates a different clinical consequence, so preservation is not limited to metabolic control alone. Protecting both helps maintain endocrine and exocrine performance and may reduce the combined burden of postoperative diabetes and impaired digestion.
Several forms of tissue stress can undermine pancreatic function at once. Direct tissue injury, inflammation, and ischemia can reduce viable glandular tissue, while disruption of pancreatic ducts or blood supply can further impair function. Preservation strategies therefore aim to limit these interacting insults rather than focusing on a single cellular target.
Endocrine and exocrine preservation should be considered as related but distinct goals. Retaining viable islet cells supports endogenous insulin production, while retaining acinar cells supports digestive enzyme secretion. A strategy could therefore protect one functional domain more effectively than the other; evaluating both is important when judging whether pancreatic function has truly been maintained.
Preserving viable tissue has consequences beyond the immediate procedure. Continued endocrine and exocrine activity can support recovery while lowering the likelihood of postoperative diabetes, impaired digestion, and pancreatitis. These outcomes make function preservation a long-term clinical objective, not merely a technical preference during disease treatment or surgery.
Surgical planning uses preservation as a guiding consideration when disease or an operation could injure pancreatic tissue. The relevant concerns include limiting tissue injury, protecting blood supply, and avoiding unnecessary disruption of ducts. This framework helps clinicians weigh intervention-related risks against the goal of retaining enough viable tissue for endocrine and exocrine function.
These conditions are specifically identified as settings where preservation principles inform clinical decision-making. In chronic pancreatitis and pancreatic tumors, disease management or intervention may threaten remaining viable tissue. Applying preservation principles focuses attention on reducing injury and retaining function where possible. The clinical value is reflected in maintained insulin production and digestion, with lower risks of postoperative diabetes, impaired digestion, or pancreatitis.
In transplantation research, preserving viable pancreatic tissue matters because retaining endogenous insulin production may improve metabolic outcomes and quality of life. This emphasis connects cellular preservation with patient-centered results: the goal is not merely to retain tissue, but to maintain enough pancreatic function to support longer-term metabolic outcomes.