Spinal Cord Hemisection

Spinal cord hemisection is an incomplete spinal cord injury in which one side of the cord is damaged, making it an important model for understanding neurological deficits and recovery. Because ascending and descending pathways cross at different levels, the lesion can produce same-side weakness and loss of vibration, proprioception, and fine touch, alongside opposite-side loss of pain and temperature below the injury, a pattern known as Brown-Séquard syndrome. In medicine, recognizing this pattern helps clinicians localize spinal cord lesions, guide diagnostic evaluation, and assess prognosis. Hemisection models also support research on neural plasticity, rehabilitation, and strategies for spinal cord repair.

Spinal Cord Hemisection - Related Videos

Research

JoVE EoE - Neuropathology

Performing Thoracic Spinal Cord Hemisection Surgery in Rats

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2025

This video demonstrates the surgical procedure for performing a thoracic spinal cord hemisection in rats. It outlines the steps to expose the T8 spinal cord segment, perform the hemisection to disrupt neural tracts on one side, and provide post-operative care.

Research

JoVE Journal - Medicine
Free Sample

Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats

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Cited by 21 •

2020

Here we describe surgical procedures to produce a reliable spinal cord lateral hemisection (HX) at the 9th thoracic level in adult rats and neurobehavioral assessments designed for detecting asymmetric deficits after such a unilateral injury.

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

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Cited by 55 •

2012

We describe two tactile sensory testing methods for acute or chronic periods of spinal cord injury in rats. These validated procedures can detect the development and maintenance of allodynia-like sensations.

Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat

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Cited by 20 •

2019

The rat thoracic spinal hemisection is a valuable and reproducible model of unilateral spinal cord injury to investigate the neural mechanisms of locomotor recovery and treatment efficacy. This article includes a detailed step-by-step guide to perform the hemisection procedure and to assess locomotor performance in an open-field arena.

Training Persons with Spinal Cord Injury to Ambulate Using a Powered Exoskeleton

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Cited by 58 •

2016

Training a person with paralysis to ambulate using a powered exoskeleton may present challenges. The goals are to present the candidate selection criteria and the training procedures for exoskeletal-assisted walking and other mobility skills that can be progressed as the participant's skill level improves.

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