Awake Child Scanning
Awake Child Scanning - Related Videos
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Despite an increase in the use of structural and functional magnetic resonance imaging (fMRI) in humans, the study of young pediatric populations remains a challenge. We present a hands-on, step-by-step video protocol including guidelines for clinicians and researchers intending to perform (f)MRI in young children.
15:42
Toddler and Preschool Child Exam
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Source: Heather Collette and Jaideep Talwalkar; Yale School of Medicine The key to a successful exam of a toddler or preschool-age child is building rapport and trust between them and the provider. Toddlers, in particular, may be wary of strangers and unwilling to cooperate with the physical exam, which is expected age-appropriate behavior. In order to provide good care and create a comfortable patient experience, clinicians need to tailor their interaction to the child's developmental stage.
10:44
Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats
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Rapid fluctuations in extracellular dopamine (DA) mediate both reward processing and motivated behavior in mammals. This manuscript describes the combined use of fast scan cyclic voltammetry (FSCV) and intra-oral tastant administration to determine how tastants alter rapid dopamine release in awake, freely moving rats.
07:56
Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure
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02:28
Leaky Scanning
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2020
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...
FAQs
Remaining conscious allows children to be studied under more natural conditions, including during rest or specific tasks. Avoiding general anesthesia also reduces anesthesia-related constraints that may affect how researchers design or interpret a study. This makes awake acquisitions especially useful when the goal is to examine neural function, cognition, communication, or behavior in a state closer to ordinary experience.
Movement can reduce the reliability of scanner data by interfering with the acquisition of brain images or physiological recordings. Awake Child Scanning therefore depends on motion-reduction strategies, comfort, and preparation that help children remain still. Researchers must treat movement control as a central part of the protocol because usable measurements require both appropriate scanning conditions and the child’s sustained cooperation.
Repeated measurements can track changes in brain maturation over time rather than providing only a single developmental snapshot. Because awake scanning supports acquisitions without general anesthesia, it can be incorporated into studies that follow children across development. This longitudinal perspective helps researchers examine changing neural function alongside cognition, communication, and features associated with neurodevelopmental conditions.
Preparation commonly combines age-appropriate explanations, practice sessions, and strategies designed to maintain comfort and reduce movement. These steps help children understand what will happen and become familiar with the demands of the session before data collection begins. Effective preparation supports cooperation without relying on general anesthesia, improving the likelihood that the planned structural or functional measurements can be acquired.
Protocols should be selected and adjusted according to each child’s age and abilities. The scan may involve rest or a specific task, but the chosen format must match what the child can understand, tolerate, and complete while remaining sufficiently still. Tailoring the protocol helps balance scientific goals with comfort and practical feasibility, which directly influences the quality of the resulting data.
In neuroscience, awake scanning can support investigations of brain maturation, cognition, communication, and neurodevelopmental conditions. Structural and functional signals can be collected while children rest or perform suitable tasks, allowing researchers to relate brain measures to developmental abilities. The approach is particularly valuable when studies require naturalistic neural assessment or repeated observations across childhood.