Een biggenperinataal asfyxiemodel om hartletsel en hemodynamiek te bestuderen na hartstilstand, reanimatie en de terugkeer van spontane circulatie

2.6K weergaven

10:55 min.

13 januari 2023

2.6K weergaven

Eydis Oddsdottir Stenersen¹^,² , Annette Olsen² , Maria Melheim³ , Rønnaug Solberg³^,⁴ , Ingrid Dannevig⁵ , Georg Schmölzer⁶^,⁷ , Po-Yin Cheung⁶^,⁷ , Britt Nakstad⁸^,⁹ , Ola Didrik Saugstad¹⁰^,¹¹ , Arild Rønnestad¹^,² , Anne Lee Solevåg²

¹Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, ²Department of Neonatal Intensive Care, Division of Pediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, ³Department of Pediatric Research, Division of Paediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, ⁴Department of Pediatrics, Vestfold Hospital Trust, ⁵Department of Anesthesiology, Oslo University Hospital Rikshospitalet, ⁶Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, ⁷Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, ⁸Division of Paediatric and Adolescent Medicine, Institute of Clinical Medicine, University of Oslo, ⁹Department of Paediatrics and Adolescent Health, University of Botswana, ¹⁰Department of Pediatric Research, Oslo University Hospital, University of Oslo, ¹¹Department of Pediatrics, Robert H Lurie Medical Research Center, Northwestern University Chicago

Dit biggenmodel omvat chirurgische instrumentatie, verstikking tot de hartstilstand, reanimatie en observatie na reanimatie. Het model maakt meerdere bemonstering per dier mogelijk en door gebruik te maken van continue invasieve arteriële bloeddruk, ECG en niet-invasieve cardiale outputmonitoring, biedt het kennis over hemodynamiek en cardiale pathofysiologie bij perinatale asfyxie en neonatale cardiopulmonale reanimatie.