Name: Duodenale-jejunale bypass-operatie bij door voeding geïnduceerde zwaarlijvige diabetische muizen (Video) | JoVE Journal
Uploaded: 2024-10-18T12:40:00.000+00:00
Duration: 8 min 50 s
Description: Leer hoe je een duodenaal-jejunale bypass uitvoert bij door voeding geïnduceerde zwaarlijvige diabetische muizen. Deze methode verbetert de glucosestofwisseling en vermindert insulineresistentie voor metabool onderzoek.

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<li>Rubino, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+mechanism+of+diabetes+control+after+gastrointestinal+bypass+surgery+reveals+a+role+of+the+proximal+small+intestine+in+the+pathophysiology+of+type+2+diabetes%5BTitle%5D)+AND+%22Ann+Surg%22%5BJournal%5D)">The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes.</a> Ann Surg. 244 (5), 741-749 (2006).</li>
<li>Rubino, F., Marescaux, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Effect+of+duodenal-jejunal+exclusion+in+a+non-obese+animal+model+of+type+2+diabetes%3A+a+new+perspective+for+an+old+disease%5BTitle%5D)+AND+%22Ann+Surg%22%5BJournal%5D)">Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease.</a> Ann Surg. 239 (1), 1-11 (2004).</li>
<li>Akalestou, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Establishing+a+successful+rat+model+of+duodenal-+jejunal+bypass%3A+A+detailed+guide%5BTitle%5D)+AND+%22Lab+Anim%22%5BJournal%5D)">Establishing a successful rat model of duodenal- jejunal bypass: A detailed guide.</a> Lab Anim. 53 (4), 362-371 (2019).</li>
<li>Yu, H. H., Hsieh, M. C., Wu, S. Y., Sy, E. D., Shan, Y. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Effects+of+duodenal-jejunal+bypass+surgery+in+ameliorating+nonalcoholic+steatohepatitis+in+diet-induced+obese+rats%5BTitle%5D)+AND+%22Diabetes+Metab+Syndr+Obes%22%5BJournal%5D)">Effects of duodenal-jejunal bypass surgery in ameliorating nonalcoholic steatohepatitis in diet-induced obese rats.</a> Diabetes Metab Syndr Obes. 12, 149-159 (2019).</li>
<li>Garciacaballero, M., Navarrete, S., Favretti, F., Celik, A., Del Castillo, D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Diabetes+surgery+in+type+2+BMI+24-29+vs+IMC+30-34+diabetic+patients%3A+is+there+differences+among+restrictive%2C+malabsorptive+and+gastric+bypass+procedures%5BTitle%5D)+AND+%22Nutr+Hosp%22%5BJournal%5D)">Diabetes surgery in type 2 BMI 24-29 vs IMC 30-34 diabetic patients: is there differences among restrictive, malabsorptive and gastric bypass procedures.</a> Nutr Hosp. 28 (2), 23-30 (2013).</li>
<li>Vidal, J., Jiménez, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Diabetes+remission+following+metabolic+surgery%3A+is+GLP-1+the+culprit%5BTitle%5D)+AND+%22Curr+Atheroscler+Rep%22%5BJournal%5D)">Diabetes remission following metabolic surgery: is GLP-1 the culprit.</a> Curr Atheroscler Rep. 15 (10), 357(2013).</li>
<li>Speck, M., Cho, Y. M., Asadi, A., Rubino, F., Kieffer, T. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Duodenal-jejunal+bypass+protects+GK+rats+from+%7Bbeta%7D-cell+loss+and+aggravation+of+hyperglycemia+and+increases+enteroendocrine+cells+coexpressing+GIP+and+GLP-1%5BTitle%5D)+AND+%22Am+J+Physiol+Endocrinol+Metab%22%5BJournal%5D)">Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1.</a> Am J Physiol Endocrinol Metab. 300 (5), E923-E932 (2011).</li>
<li>Ashrafian, H., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Metabolic+surgery%3A+an+evolution+through+bariatric+animal+models%5BTitle%5D)+AND+%22Obes+Rev%22%5BJournal%5D)">Metabolic surgery: an evolution through bariatric animal models.</a> Obes Rev. 11 (12), 907-920 (2010).</li>
<li>Rao, R. S., Rao, V., Kini, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Animal+models+in+bariatric+surgery--a+review+of+the+surgical+techniques+and+postsurgical+physiology%5BTitle%5D)+AND+%22Obes+Surg%22%5BJournal%5D)">Animal models in bariatric surgery--a review of the surgical techniques and postsurgical physiology.</a> Obes Surg. 20 (9), 1293-1305 (2010).</li>
<li>Im, Y. R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((A+systematic+review+of+animal+models+of+NAFLD+finds+high-fat%2C+high-fructose+diets+most+closely+resemble+human+NAFLD%5BTitle%5D)+AND+%22Hepatology%22%5BJournal%5D)">A systematic review of animal models of NAFLD finds high-fat, high-fructose diets most closely resemble human NAFLD.</a> Hepatology. 74 (4), 1884-1901 (2021).</li>
<li>Kleinert, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Animal+models+of+obesity+and+diabetes+mellitus%5BTitle%5D)+AND+%22Nat+Rev+Endocrinol%22%5BJournal%5D)">Animal models of obesity and diabetes mellitus.</a> Nat Rev Endocrinol. 14 (3), 140-162 (2018).</li>
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<li>Buchwald, H., Varco, R. L., Moore, R. B., Schwartz, M. Z. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Intestinal+bypass+procedures.+Partial+ileal+bypass+for+hyperlipidemia+and+jejunoileal+bypass+for+obesity%5BTitle%5D)+AND+%22Curr+Probl+Surg%22%5BJournal%5D)">Intestinal bypass procedures. Partial ileal bypass for hyperlipidemia and jejunoileal bypass for obesity.</a> Curr Probl Surg. , 1-51 (1975).</li>
<li>DeMaria, E. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Bariatric+surgery+for+morbid+obesity%5BTitle%5D)+AND+%22N+Engl+J+Med%22%5BJournal%5D)">Bariatric surgery for morbid obesity.</a> N Engl J Med. 356 (21), 2176-2183 (2007).</li>
<li>Bolling, C. F., Armstrong, S. C., Reichard, K. W., Michalsky, M. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Metabolic+and+bariatric+surgery+for+pediatric+patients+with+severe+obesity%5BTitle%5D)+AND+%22Pediatrics%22%5BJournal%5D)">Metabolic and bariatric surgery for pediatric patients with severe obesity.</a> Pediatrics. 144 (6), e20193224(2019).</li>
<li>Mason, E. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Gastric+bypass+for+morbid+obesity%5BTitle%5D)+AND+%22Surg+Annu%22%5BJournal%5D)">Gastric bypass for morbid obesity.</a> Surg Annu. 11, 99-126 (1979).</li>
<li>Cheng, Y., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Sleeve+gastrectomy+with+bypass+of+proximal+small+intestine+provides+better+diabetes+control+than+sleeve+gastrectomy+alone+under+postoperative+high-fat+diet%5BTitle%5D)+AND+%22Obes+Surg%22%5BJournal%5D)">Sleeve gastrectomy with bypass of proximal small intestine provides better diabetes control than sleeve gastrectomy alone under postoperative high-fat diet.</a> Obes Surg. 29 (1), 84-92 (2019).</li>
<li>Rubino, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+role+of+the+small+bowel+in+the+regulation+of+circulating+ghrelin+levels+and+food+intake+in+the+obese+Zucker+rat%5BTitle%5D)+AND+%22Endocrinology%22%5BJournal%5D)">The role of the small bowel in the regulation of circulating ghrelin levels and food intake in the obese Zucker rat.</a> Endocrinology. 146 (4), 1745-1751 (2005).</li>
<li>Zachariah, P. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Compared+to+sleeve+gastrectomy%2C+duodenal-jejunal+bypass+with+sleeve+gastrectomy+gives+better+glycemic+control+in+T2DM+patients%2C+with+a+lower+%CE%B2-cell+response+and+similar+appetite+sensations%3A+mixed-meal+study%5BTitle%5D)+AND+%22Obes+Surg%22%5BJournal%5D)">Compared to sleeve gastrectomy, duodenal-jejunal bypass with sleeve gastrectomy gives better glycemic control in T2DM patients, with a lower β-cell response and similar appetite sensations: mixed-meal study.</a> Obes Surg. 26 (12), 2862-2872 (2016).</li>
<li>Jiang, B., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Role+of+proximal+intestinal+glucose+sensing+and+metabolism+in+the+blood+glucose+control+in+type+2+diabetic+rats+after+duodenal+jejunal+bypass+surgery%5BTitle%5D)+AND+%22Obes+Surg%22%5BJournal%5D)">Role of proximal intestinal glucose sensing and metabolism in the blood glucose control in type 2 diabetic rats after duodenal jejunal bypass surgery.</a> Obes Surg. 32 (4), 1119-1129 (2022).</li>
<li>Han, H. F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Duodenal-jejunal+bypass+increases+intraduodenal+bile+acids+and+upregulates+duodenal+SIRT1+expression+in+high-fat+diet+and+streptozotocin-induced+diabetic+rats%5BTitle%5D)+AND+%22World+J+Gastroenterol%22%5BJournal%5D)">Duodenal-jejunal bypass increases intraduodenal bile acids and upregulates duodenal SIRT1 expression in high-fat diet and streptozotocin-induced diabetic rats.</a> World J Gastroenterol. 28 (31), 4338-4350 (2022).</li>
<li>Yan, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Reduction+of+intestinal+electrogenic+glucose+absorption+after+duodenojejunal+bypass+in+a+mouse+model%5BTitle%5D)+AND+%22Obes+Surg%22%5BJournal%5D)">Reduction of intestinal electrogenic glucose absorption after duodenojejunal bypass in a mouse model.</a> Obes Surg. 23 (9), 1361-1369 (2013).</li>
<li>Arble, D. M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Metabolic+comparison+of+one-anastomosis+gastric+bypass%2C+single-anastomosis+duodenal-switch%2C+Roux-en-Y+gastric+bypass%2C+and+vertical+sleeve+gastrectomy+in+rat%5BTitle%5D)+AND+%22Surg+Obes+Relat+Dis%22%5BJournal%5D)">Metabolic comparison of one-anastomosis gastric bypass, single-anastomosis duodenal-switch, Roux-en-Y gastric bypass, and vertical sleeve gastrectomy in rat.</a> Surg Obes Relat Dis. 14 (12), 1857-1867 (2018).</li>
<li>Liang, Y., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Duodenal-jejunal+bypass+surgery+reverses+diabetic+phenotype+and+reduces+obesity+in+db%2Fdb+Mice%5BTitle%5D)+AND+%22Curr+Chem+Genom+Transl+Med%22%5BJournal%5D)">Duodenal-jejunal bypass surgery reverses diabetic phenotype and reduces obesity in db/db Mice.</a> Curr Chem Genom Transl Med. 11, 41-49 (2017).</li>
<li>Barataud, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Absence+of+role+of+dietary+protein+sensing+in+the+metabolic+benefits+of+duodenal-jejunal+bypass+in+the+mouse%5BTitle%5D)+AND+%22Sci+Rep%22%5BJournal%5D)">Absence of role of dietary protein sensing in the metabolic benefits of duodenal-jejunal bypass in the mouse.</a> Sci Rep. 7, 44856(2017).</li>
<li><a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Close-up+on+lab+animal+microsurgery%5BTitle%5D)+AND+%22Lab+Anim+%28NY%29%22%5BJournal%5D)">Close-up on lab animal microsurgery.</a> Lab Anim (NY). 35 (1), 43(2006).</li>
<li>Couceiro, J., Castro, R., Tien, H., Ozyurekoglu, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Step+by+step%3A+microsurgical+training+method+combining+two+nonliving+animal+models%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">Step by step: microsurgical training method combining two nonliving animal models.</a> J Vis Exp. (99), e52625(2015).</li>
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</ol>

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```

duodenale-jejunale bypass-operatie bij door voeding geïnduceerde zwaarlijvige diabetische muizen

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice

Duodenale-jejunale bypass-operatie bij door voeding geïnduceerde zwaarlijvige diabetische muizen

The prevalence of obesity and type 2 diabetes is a serious global health concern. Obesity is a major pathogenic factor in type 2 diabetes, cardiovascular ...

duodenal-jejunal-bypass-surgery-in-diet-induced-obese-diabetic-mice

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Tal van studies met behulp van maag-bypass rat modellen zijn onlangs uitgevoerd om de onderliggende fysiologische mechanismen van Roux-en-Y gastric bypass-operaties te ontdekken. Dit artikel beoogt aan te tonen en de technische en experimentele details van onze gepubliceerde gastric bypass rat model te bespreken voordelen en beperkingen van deze experimentele programma te begrijpen.

Roux-en-Y Gastric Bypass operatie bij ratten

This video describes a bariatric surgery-Roux-en-Y procedure. This involves the cutting of the jejunum- the middle portion of the intestine- to generate two intestinal limbs. The biliary limb is attached to the existing intestinal loop and the alimentary limb is attached to the stomach, creating a gastric bypass. The gastric bypass created here helps to decrease the nutrient uptake and efficiently reduces body weight.

Roux-en-Y Gastric Bypass Procedure: A Bariatric Surgical Procedure for Gastric Resectioning in Murine Model

Bariatrische chirurgie is de meest efficiënte manier om het lichaamsgewicht te verminderen en de dodelijke metabole complicaties (diabetes, obesitas en dyslipidemie) die vaak gepaard gaan met morbide obesitas. Muismodellen van bariatrische chirurgie vormen een unieke aanwinst voor het ontcijferen van moleculaire mechanismen achter de gunstige effecten van deze operaties op diabetes, hypertensie en dyslipidemie.

Technieken van Sleeve Gastrectomie en Modified Roux-en-Y Gastric Bypass in Muizen

Dit protocol demonstreert het isoleren van muizen eiland en zaait op een decellularized steiger. Steigergesteunde eilandjes werden getransplanteerd in het epididymale vetpaneel van streptozotocine (STZ) geïnduceerde diabetische muizen. Islets overleefden op de transplantatieplaats en reverseerde de hyperglycemische conditie.

Steiger-gesteunde transplantatie van eilanden in het epididymale vetpaneel van diabetische muizen

Het volgende beschrijft de prestaties van verticale sleeve Gastrectomie in muizen. Dit is een soort gewichtsverlies chirurgie dat verwijdering van ongeveer 70% van de maag.

Een lymfkliertest Model van verticale Sleeve Gastrectomie

Dit protocol is voor de uitvoering van een-wapendrager maagomleiding (OAGB) op de rat. De exploitant voert een lange en tubulaire-geniet maag zakje gevolgd door wapendrager hand genaaid. Voor dit model reproduceert de exploitant de verhouding tussen biliopancreatic en gemeenschappelijke ledemaat bij de mens; Daarom meet de ledemaat biliopancreatic 35 cm.

Één-wapendrager maagomleiding (OAGB) bij ratten

De prevalentie van diabetes en obesitas neemt wereldwijd voortdurend toe. De mechanismen tussen diabetes, obesitas en de bijbehorende mortaliteit en comorbiditeit moeten verder worden onderzocht. Hier presenteren we een protocol voor mouwgastrectomie (SG) bij dieren als een ongecompliceerd preklinisch model van bariatrische chirurgie.

Mouw Gastrectomie in muizen met behulp van chirurgische clips

Roux-en-Y gastric bypass (RYGB) wordt uitgevoerd om obesitas en diabetes te behandelen. De mechanismen die ten grondslag liggen aan de werkzaamheid van RYGB zijn echter niet volledig begrepen en studies worden beperkt door technische problemen die leiden tot een hoge mortaliteit in diermodellen. Dit artikel bevat instructies voor het uitvoeren van RYGB bij ratten met hoge slagingspercentages.

Een protocol voor Roux-en-Y gastric bypass bij ratten met behulp van lineaire nietmachines

Single-anastomosis duodeno-ileale bypass (SADI-S) is een opkomende bariatrische procedure met belangrijke metabole effecten. In dit artikel presenteren we een betrouwbaar en reproduceerbaar model van SADI-S bij muizen.

Single-Anastomosis Duodeno-Ileal Bypass met Sleeve Gastrectomy Model bij muizen

Bepaling van maaglediging Niet-invasieve...

Beoordeling van de maaglediging in niet-obese diabetische muizen met behulp van een [<sup&gt; 13</sup&gt; C]-octaanzuur ademtest

Leer hoe je een duodenaal-jejunale bypass uitvoert bij door voeding geïnduceerde zwaarlijvige diabetische muizen. Deze methode verbetert de glucosestofwisseling en vermindert insulineresistentie voor metabool onderzoek.

Duodenale-jejunale bypass-operatie bij door voeding geïnduceerde zwaarlijvige diabetische muizen

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