Name: Saccharomyces cerevisiae Modellen van de ziekte van Alzheimer om genen, mutaties en chemicaliën te screenen die de productie van amyloïde bèta beïnvloeden door γ-secretase (Video) | JoVE Journal
Uploaded: 2025-06-24T12:50:00.000+00:00
Duration: 11 min 57 s
Description: Leer gamma-secretase reconstitutie in Saccharomyces cerevisiae om FAD-mutaties te onderzoeken en suppressor-mutaties te identificeren die Abeta 42 verlagen.

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<li>Self, W. K., Holtzman, D. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Emerging+diagnostics+and+therapeutics+for+Alzheimer%27s+disease%5BTitle%5D)+AND+%22Nat+Med%22%5BJournal%5D)">Emerging diagnostics and therapeutics for Alzheimer's disease.</a> Nat Med. 29, 2187-2199 (2023).</li>
<li>Solopova, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Fatal+iatrogenic+cerebral+%CE%B2-amyloid-related+arteritis+in+a+woman+treated+with+lecanemab+for+Alzheimer%27s+disease%5BTitle%5D)+AND+%22Nat+Commun%22%5BJournal%5D)">Fatal iatrogenic cerebral β-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer's disease.</a> Nat Commun. 14 (1), 8220(2023).</li>
<li>Zhang, Y., Chen, H., Li, R., Sterling, K., Song, W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Amyloid+%CE%B2-based+therapy+for+Alzheimer%27s+disease%3A+challenges%2C+successes+and+future%5BTitle%5D)+AND+%22Signal+Transduct+Target+Ther%22%5BJournal%5D)">Amyloid β-based therapy for Alzheimer's disease: challenges, successes and future.</a> Signal Transduct Target Ther. 8 (1), 248(2023).</li>
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Saccharomyces cerevisiae Modellen van de ziekte van Alzheimer om genen, mutaties en chemicaliën te screenen die de productie van amyloïde bèta beïnvloeden door γ-secretase (Video) | JoVE Journal

Saccharomyces cerevisiae Modellen van de ziekte van Alzheimer om genen, mutaties en chemicaliën te screenen die de productie van amyloïde bèta beïnvloeden door γ-secretase

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